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  • 1
    Online Resource
    Online Resource
    Weinheim :Wiley-VCH,
    UID:
    almafu_9959327499002883
    Format: 1 online resource (xxvi, 538 pages) : , illustrations
    ISBN: 9783527630035 , 3527630031 , 9783527630042 , 352763004X
    Content: Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development. Of interest to.
    Note: General aspects. Optimizing drug therapy by analogues / Janos Fischer [and others] -- Standalone drugs / J̀nos Fischer [and others] -- Application of molecular modeling in analogue-based drug Ddscovery / Gyorgy G. Ferenczy -- Issues for the patenting of analogues / Stephen C. Smith -- Analogue classes. Dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes / Jens-Uwe Peters, Patrizio Mattei -- Phosphodiesterase 5 inhibitors to treat erectile dysfunction / Nils Griebenow, Helmut Haning, Erwin Bischoff -- Rifamycins, antibacterial antibiotics and their new applications / Enrico Selva, Giancarlo Lancini -- Monoterpenoid indole alkaloids, CNS and anticancer drugs / Andr̀s Nemes -- Anthracyclines, optimizing anticancer analogues / Federico-Maria Arcamone -- Paclitaxel and epothilone analogues, anticancer drugs / Paul W Erhardt, Mohammad El-Dakdouki -- Selective serotonin reuptake inhibitors for the treatment of depression / Wayne E. Childers, David P. Rotella -- Muscarinic receptor antagonists in the treatment of COPD / Matthias Grauert, Michael P. Pieper, Paola Casarosa -- Adrenoceptor agonists and asthma / Giovanni Gaviraghi -- Case histories. Liraglutide, a GLP-1 analogue to treat diabetes / Lotte B. Knudsen -- Eplerenone: selective aldosterone antagonist / Jaroslav Kalvoda, Marc de Gasparo -- Clevudine, to treat hepatitis B viral infection / Ashoke Sharon, Ashok K. Jha, Chung K. Chu -- Rilpivirine, a non-nucleoside reverse transcriptase inhibitor to treat HIV-1 / Jerome Guillemont [and others] -- Tipranavir, a non-peptidic protease inhibitor for multi-drug resistant HIV / Suvit Thaisrivongs, Joseph W. Strohbach, Steve R. Turner -- Lapatinib, an anticancer kinase inhibitor / Karen Lackey -- Dasatinib, a kinase inhibitor to treat chronic myelogenous leukemia / Jagabandhu Das, Joel C. Barrish -- Venlafaxine and desvenlafaxine, selective norepinephrine and serotonin reuptake inhibitors to treat major depressive disorder / Magid Abou-Gharbia, Wayne E. Childers.
    Additional Edition: Print version: Analogue-based drug discovery II. Weinheim : Wiley-VCH, ©2010 ISBN 9783527325498
    Language: English
    Keywords: Electronic books. ; Electronic books. ; Electronic books.
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