UID:
almafu_9958127424702883
Format:
1 online resource (223 p.)
Edition:
1st ed.
ISBN:
1-119-94098-2
,
1-280-59925-1
,
9786613629081
,
1-118-38773-2
,
1-119-94068-0
,
1-119-94067-2
Content:
Over the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments. The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiment
Note:
Includes index.
,
Replacing Animal Models; Contents; Contributors; Preface; Section 1 Introductory Material; 1 Potential Advantages of Using Biomimetic Alternatives; 2 Overview of Biomimetic Alternatives; Section 2 Culture Methods; 3 Pancreatic Islets; 4 Endometrial Organoid Culture; 5 Modelling Lymphatic and Blood Capillary Patterning; 6 Precision-cut Lung Slices (PCLS); 7 Human Colon Tissue in Organ Culture; 8 Fetal Organ Culture; 9 Design of a Mechanical Loading Device to Culture Intact Bovine Spinal Motion Segments under Multiaxial Motion; 10 Magnetic Assembly of Tissue Surrogates
,
11 Assembly of Renal Tissues by Cellular Self-organizationSection 3 Case Studies of Use; 12 Hierarchical Screening of Pathways: Using Cell and Organ Cultures to Reduce use of Transgenic Mice; 13 Lung Organoid Culture to Study Responses to Viruses; 14 Organ-cultured Human Skin for the Study of Epithelial Cell Invasion of Stroma; 15 Organotypic Mandibular Cultures for the Study of Inflammatory Bone Pathology; 16 Three-dimensional, High-density and Tissue Engineered Culture Models of Articular Cartilage; 17 Concluding Remarks
,
Appendix 1 Sources of funding for development of culture-based alternativesAppendix 2 Databases and web-based discussions relevant to development of alternatives; Index; Color Plate
,
English
Additional Edition:
ISBN 0-470-97425-7
Language:
English
Keywords:
Aufsatzsammlung
;
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781119940685
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781119940685
