UID:
almafu_9959328796902883
Format:
1 online resource (xxi, 630 pages)
Edition:
First edition.
ISBN:
9783527676545
,
3527676546
,
9783527676552
,
3527676554
,
9783527676569
,
3527676562
,
9783527676576
,
3527676570
,
1306254833
,
9781306254830
Series Statement:
Methods and principles in medicinal chemistry
Content:
The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 15 highly informative chapters. Using well-documented case studies from drug development projects over the past decade, this handbook and ready reference demonstrates the current importance and future potential of natural products as drug precursors, highlighting the lessons learned and pointing to future directions in the field. The examples are carefully chosen so as to represent a wide range of chemical structures as well a.
Note:
Natural products as drugs and leads to drugs: an introduction and perspectives as of the end of 2012 -- Natural product-derived and natural product-inspired compound collections -- Chemistry and biology of epothilones -- Taxol, taxoids, and related taxanes -- Camptothecin and analogs -- A short history of the discovery and development of naltrexone and other morphine derivatives -- Lincosamide antibacterials -- Platensimycin and platencin -- From natural product to new diabetes therapy: phlorizin and the discovery of SGLT2 inhibitor clinical candidates -- Aeruginosins as thrombin inhibitors -- Macrolides and antifungals via biotransformation -- Unnatural nucleoside analogs for antisense therapy -- Hybrid natural products -- Rethinking the role of natural products: function-oriented synthesis bryostatin, and bryologs -- Cyclopamine and congeners -- Hybrids, congeners, mimics and constrained variants spanning 30 years of natural products chemistry: a personal retrospective.
Additional Edition:
Print version: Natural products in medicinal chemistry. Weinheim : Wiley-VCH, [2014] ISBN 9783527332182
Language:
English
Keywords:
Electronic books.
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Electronic books.
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Electronic books.
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Electronic books.
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Electronic books.
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Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527676545
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527676545
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527676545
