UID:
almafu_9959328826702883
Format:
1 online resource (xviii, 230 pages)
ISBN:
9780470686423
,
0470686421
,
9780470686430
,
047068643X
,
047074460X
,
9780470744604
Content:
This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of "omic" data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations.
Note:
Biomarkers and bioinformatics -- Review of fundamental statistical concepts -- Biomarker-based prediction models : design and interpretation principles -- An introduction to the discovery and analysis of genotype-phenotype associations -- Integrative approaches to genotype-phenotype association discovery / Ana Dopazo -- Biomarkers and gene expression data analysis -- Advances in biomarker discovery with gene expression data / Haiying Wang and Huiru Zheng -- Proteomics and metabolomics for biomarker discovery : an introduction to spectral data analysis -- Data integration in proteomics and metabolomics for biomarker discovery / Kenneth Bryan -- Disease biomarkers and biological interaction networks -- Commentary on disease biomarkers and biological interaction networks / Zhongming Zhao -- Integrative data analysis for biomarker discovery -- Data integration : the next big hope? / Yves Moreau -- Information resources and software tools for biomarker discovery -- Challenges and research directions in bioinformatics and biomarker discovery -- Towards building knowledge-based assistants for intelligent data analysis in biomarker discovery / Riccardo Bellazzi -- Accompanying commentary on challenges and opportunities of bioinformatics in disease biomarker discovery / Gary B. Fogel.
Additional Edition:
Print version: Azuaje, Francisco. Bioinformatics and biomarker discovery. Hoboken, NJ : John Wiley & Sons, 2010 ISBN 9780470744604
Additional Edition:
ISBN 047074460X
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
DOI:
10.1002/9780470686423
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470686423
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470686423
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470686423
