UID:
almafu_9960072714302883
Umfang:
1 online resource (501 p.)
ISBN:
1-281-03315-4
,
9786611033156
,
0-08-053705-7
Inhalt:
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology.Key Features* Provides the late
Anmerkung:
Description based upon print version of record.
,
Front Cover; Mucosal Vaccines; Copyright Page; Contents; Contributors; Preface; Part I: Introduction; Chapter 1. Mucosal Immunoprophylaxis: An Introductory Overview; I. Introduction; II. Elements of Mucosal Immune System Involved in Immune Response; III. Immunoprophylaxis by the Mucosal Route; IV. Mucosal Adjuvants and Vaccine Delivery Systems; V. Potential Limitations of Mucosal Immunization; VI. Concluding Remarks; References; Part II: Principles of Mucosal Vaccination; Chapter 2. Application of Basic Principles of Mucosal Immunity to Vaccine Development; I. Introduction
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II. Mucosal Immune System OrganizationIII. Characteristics of Regulatory T Cells in the Mucosal Immune System; IV. Multiple Roles for T Cells and Cytokines in Mucosal Immunity; V. The Role of Epithelial Cells in Mucosal Immunity; VI. Mucosal Effector Functions for IgA; VII. Diverse Antigen Delivery Systems for the Induction of Distinct Mucosal Immune Responses; VIII. Summary; References; Chapter 3. Antigen Uptake by M Cells for Effective Mucosal Vaccines; I . Introduction; II. Antigen Sampling across Stratified Epithelial Barriers; III. Antigen Sampling across Simple Epithelia
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IV. M Cell Organization and FunctionV. Differentiation of the FAE and M Cells; VI. Interactions of Microorganisms with M Cells; VII. M Cells and Mucosal Vaccine Strategies; VIII. Conclusions; References; Part III: Mucosal Modulation for Induction of Effective Immunity; Chapter 4. Cholera Toxin as a Mucosal Adjuvant; I. Introduction; II. The Molecular and Cellular Biology of Cholera Toxin; III. Cholera Toxin as a Mucosal Immunogen; IV. Cholera Toxin as a Mucosal Adjuvant: General Characteristics; V. Role of CT Subunits in Mucosal Adjuvanticity; VI. Site of Adjuvant Activity
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VII. Antigen Uptake across Epithelium or into Lymphoid FolliclesVIII. Cellular Targets of Adjuvanticity; IX. Summary; References; Chapter 5. Use of Escherichia coli Heat-Labile Enterotoxin as an Oral Adjuvant; I. Introduction; II. Biological and Immunological Properties of Cholera Toxin and LT; III. Comparison of LT and CT; IV. Cellular Targets of Enterotoxin Action; V. Mucosal (Oral) Tolerance/Adjuvant Properties of LT; VI. Toward a Practical Adjuvant; VII. Summary; References; Chapter 6. Consideration of Mucosally Induced Tolerance in Vaccine Development; I. Introduction
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II. Mucosal Immune System for Vaccines and Mucosally Induced ToleranceIII. Protein Vaccine Diphtheria Toxoid (DT) Induces Mucosal Tolerance; IV. Cholera Toxin B Subunit as Transmucosal and Carrier-Delivery System for Induction of Systemic Tolerance; V. Mechanisms of Oral Tolerance: Role of aß and ?d T Cells; VI. Clinical Application of Oral Tolerance; References; Part IV: Current and New Approaches for Mucosal Vaccine Delivery; Chapter 7. Attenuated Salmonella as Vectors for Oral Immunization; I. Attenuated Salmonella for Use as Live Oral Vaccines
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II. Vectors for the Expression of Foreign Epitopes
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English
Weitere Ausg.:
ISBN 0-12-410580-7
Sprache:
Englisch
