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Format: 1 online resource (656 p.)

ISBN: 9780081000533 , 0081000537

Content: "Biotechnology for Biofuel Production and Optimization is the compilation of current research findings that cover the entire process of biofuels production from manipulation of genes and pathways to organisms and renewable feedstocks for efficient biofuel production as well as different cultivation techniques and process scale-up considerations. This book captures recent breakthroughs in the interdisciplinary areas of systems and synthetic biology, metabolic engineering, and bioprocess engineering for renewable, cleaner sources of energy."--

Note: Description based upon print version of record. , Front Cover; Biotechnology for Biofuel Production and Optimization; Copyright; Contents; Contributors; Preface; Chapter 1: Engineering Central Metabolism for Production of Higher Alcohol-based Biofuels; 1.1 Introduction: Longer Chain Bioalcohols as Gasoline Alternatives; 1.2 Producing Longer Chain Alcohols Through the Central Metabolism; 1.2.1 Fermentative Pathways; ABE Pathway in Clostridium Acetobutylicum; ABE Pathway in Heterologous Hosts; Extending the ABE Pathway; 1.2.2 Non-Fermentative Pathways; Amino Acid Biosynthesis/Ehrlich Pathway; Reverse β -Oxidation Pathway , Amino Acid Oxidation/Ehrlich Pathway1.2.3 Opportunities for Further Improvement; 1.3 Strategies for Improving Higher Alcohol Production; 1.3.1 Approaches to Enhance Enzyme and Pathway Function; 1.3.2 Engineering Microbial Hosts to Enhance Cofactor and Precursor Availability; 1.3.3 Engineering Microbial Hosts to Address Product Toxicity; Understanding Product Toxicity; Adaptive Evolutionary Approaches to Overcoming Product Toxicity; Targeted Approaches to Overcoming Product Toxicity; Isolating and Engineering More Tolerant Hosts , 1.4 Successes and Challenges on the Path Towards Commercialization1.4.1 Examples of Successful Commercialization; 1.4.2 Product Separation; 1.4.3 Commercially Viable Hosts; 1.4.4 Alternative Feedstocks; 1.5 Outlook: Overcoming Roadblocks; Acknowledgments; References; Chapter 2: Secondary Metabolism for Isoprenoid-based Biofuels; 2.1 Introduction; 2.2 Biosynthesis of Isoprenoids; 2.2.1 The MVA Pathway; 2.2.2 Variations of MVA Pathway-Example of Archaeal MVA Pathway; 2.2.3 MEP Pathway; 2.2.4 Regulations of the Isoprenoid Pathways , 2.2.5 Stoichiometry of the MVA and the MEP Pathways and Choice of Pathways for Engineering2.2.6 Prenyl Diphosphate Synthase and Terpene Synthase; 2.3 Engineering of the Isoprenoid Pathways for Biofuels Production; 2.3.1 Limitations of Plants Platform for Isoprenoid Production; 2.3.2 Development of Isoprenoids Pathways in Microbial Platforms; Engineering of the MEP pathway; Engineering of the MVA pathway for amorphadiene production in E. coli ; Engineering of the MVA pathway for amorphadiene production in yeast; Efforts to engineer the MEP pathway in yeast , 2.4 Engineering of the MVA Pathway for Isoprenoid-based Biofuels2.4.1 Sesquiterpene Biofuels (C 15); Farnesene; Bisabolene; Farnesol; 2.4.2 Monoterpene Biofuels (C 10); 2.4.3 Hemiterpene Biofuels (C 5); 2.5 Concluding Remarks; Acknowledgments; References; Chapter 3: Metabolic Engineering for Fatty Acid and Biodiesel Production; 3.1 Introduction; 3.2 Overview of Lipid Metabolism; 3.3 Modified Fatty Acid Species; 3.4 Conversion of Lipids and Fatty Acids into Biodiesel; 3.5 Conversion of Fatty Acids into Additional Oleochemicals; 3.6 Host Organism; 3.7 Conclusion; References , Chapter 4: Pathway and Strain Design for Biofuels Production , English

Additional Edition: ISBN 9780444634757

Additional Edition: ISBN 0444634754

Language: English