UID:
almafu_9960073721002883
Format:
1 online resource (325 p.)
Edition:
1st ed.
ISBN:
9780081001066
,
0081001061
Series Statement:
Woodhead Publishing Series in Biomedicine ; Number 78
Content:
Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of anima
Note:
Description based upon print version of record.
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Front Cover; Modeling Neuropsychiatric Disorders in Laboratory Animals; Copyright; Dedication; Contents; Introduction; About the author; Acknowledgments; Chapter 1: What is an animal model of a neuropsychiatric disorder?; 1.1 Introduction; 1.2 What is a neuropsychiatric disorder? (and what is not?); 1.3 What is an animal model of a neuropsychiatric disorder?; 1.3.1 Tests versus models; 1.3.2 State versus trait; 1.4 General types of animal models; 1.4.1 Pharmacologic models; 1.4.2 Lesion models; 1.4.3 Genetic models; 1.4.4 Environment and experience-based models
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1.4.5 Gene by environment interaction models1.5 Animal model or model animal?; 1.6 Validating an animal model; 1.6.1 What is meant by the "validity" of an animal model?; 1.6.2 Early conceptualizations of the validation of animal models; 1.6.3 Face validity; 1.6.4 Construct and etiologic validity; 1.6.5 Genetic construct validity; 1.6.6 Environmental construct validity; 1.6.7 Predictive validity; 1.6.8 Reliability; 1.6.9 Convergent and discriminant validity; 1.6.10 Population validity; 1.6.11 Relevance, generalizability, and the importance of replication
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1.6.12 A reexamination of the "classic" validation criteria: Belzung and Lemoine (2011) 1.7 Endophenotypes and biologic markers; 1.8 Chapter overview and perspectives; References; Chapter 2: What can animal models tell us about depressive disorders?; 2.1 Depressive disorders; 2.2 Neurobiology of depressive disorders; 2.2.1 Brain structural alterations in depressive disorders; 2.2.2 Functional alterations in depressive disorders; 2.3 Relationship to normalcy; 2.3.1 Conservation of resources; 2.3.2 Competition for social rank; 2.3.3 Social attachment; 2.3.5 Sickness behavior
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2.4 Endophenotypes of depressive disorders2.4.1 Anhedonia; 2.4.2 Negative processing bias and enhanced reactivity to negative stimuli; 2.4.3 Cognitive vulnerability, rumination, and neuroticism; 2.4.4 Electrophysiologic endophenotypes; 2.4.5 Neuroanatomical endophenotypes; 2.5 Gene variants associated with depression; 2.6 Measuring endophenotypes in rodent models; 2.6.1 Anhedonia; 2.6.1.1 Saccharin/sucrose preference test; 2.6.1.2 Conditioned place preference; 2.6.1.3 Intracranial self-stimulation; 2.6.1.4 Variable progressive ratio reinforcement
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2.6.1.5 Response bias probabilistic reward task2.6.2 Negative processing bias; 2.6.2.1 Increased reactivity to aversive stimuli; 2.6.2.2 Probabilistic reversal learning; 2.6.2.3 Reactivity to emotionally ambiguous cues; 2.6.3 Electrophysiologic measures; 2.6.4 Tests or models? Both or neither?; 2.7 Animal models; 2.7.1 Learned helplessness; 2.7.2 Chronic adult stress; 2.7.3 Early life stress; 2.7.4 Social stress; 2.7.5 Pharmacologic model; 2.7.6 Lesion model; 2.7.7 Genetic models; 2.7.8 Gene by environment interaction models; 2.8 Model animals
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2.9 Chapter overview and perspectives
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English
Additional Edition:
ISBN 9780081000991
Additional Edition:
ISBN 0081000995
Language:
English
Keywords:
Electronic books.
