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Involvement of Degradation Pathways and Neuron-To-neuron Transmission in Alzheimer's Disease (2012)

Agholme, Lotta

Linkopings Universitet

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UID:

almafu_9961025000502883

Ausgabe: 1st ed.

ISBN: 9789175198484

Inhalt: This dissertation explores the mechanisms of Alzheimer's disease (AD), focusing on degradation pathways and neuron-to-neuron transmission. It examines the role of β-amyloid and tau protein aggregates in sporadic AD, where defective degradation systems like lysosomes and proteasomes contribute to disease progression. The research aims to improve neuronal models to study the effects of decreased proteasome function on tau and axonal transport. It also investigates the proteasome inhibition's impact on Aβ accumulation and the potential for Aβ oligomers to transfer between neurons. The findings suggest that enhancing degradation systems or preventing Aβ transmission could offer new treatment avenues for AD. This work is intended for researchers and professionals in neurology and pathology.

Sprache: Englisch

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