UID:
almahu_9948025390902882
Format:
1 online resource (242 p.)
ISBN:
1-281-11893-1
,
9786611118938
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0-08-053745-6
Content:
Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions.This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance.This book will be of interest to those working in all areas of research affected by NPY, such as food intak
Note:
Description based upon print version of record.
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Front Cover; Neuropeptide Y and Drug Development; Copyright Page; Contents; Contributors; Preface; Chapter 1. Multiple receptors and multiple actions; 1.1 Multiple receptor types; 1.2 Yl receptors; 1.3 Y2 receptors; 1.4 Y3 receptors; 1.5 PPl/Y receptors; 1.6 Y5 receptors; 1.7 Other receptors and targets; Acknowledgements; References; Chapter 2. Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes; 2.1 Introduction; 2.2 Pathways mediating the central effects of neuropeptide Y; 2.3 Neuropeptide Y and the regulation of feeding; 2.4 NPY and fat deposition
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2.5 NPY and pituitary function2.6 Other central effects of NPY; 2.7 NPY and obesity; 2.8 NPY, bulimia and anorexia nervosa; 2.9 NPY and diabetes; 2.10 Conclusion; References; Chapter 3. Neuropeptide Y in sympathetic nerves: evidence for Yl receptor mediated vascular control; 3.1 Introduction; 3.2 Prejunctional regulation of sympathetic transmitter release; 3.3 NPY in plasma and its clearance; 3.4 NPY in sympathetic neurotransmission; 3.5 NPY and cardiovascular disorders; References
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Chapter 4. Neuropeptide Y receptor types in mammalian brain: species differences and status in the human central nervous system4.1 Introduction; 4.2 Comparative distribution of NPY receptor types; 4.3 Functional significance of various NPY receptor types; 4.4 Conclusion; Acknowledgements; References; Chapter 5. Extraordinary structural diversity of NPY-family receptors; 5.1 Introduction; 5.2 Yl receptors; 5.3 Y2 receptors; 5.4 Pancreatic polypeptide receptors; 5.5 Discussion; Acknowledgements; References; Chapter 6. The importance of various parts of the NPY molecule for receptor recognition
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6.1 Neuropeptide Y: sequence and secondary structure6.2 Analoguesfor the characterization of the receptor types; 6.3 Structure-activity relationships; 6.4 A model of active conformations; References; Chapter 7. Peptide antagonists of neuropeptide Y: design, structure and pharmacological characterization; 7.1 Background; 7.2 Design of small peptide antagonists of neuropeptide Y; 7.3 High-affinity peptide ligands; 7.4 Peptide dimers as potent NPY antagonists; 7.5 Pentapeptide dimers and multimers; Conclusion; Acknowledgements; References
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Chapter 8. SR 120819A or the first generation of orally active Yl receptor antagonists8.1 Introduction; 8.2 Discovery of SR 120819A; 8.3 Biochemical profile of SR 120819A; 8.4 In vitro functional studies with SR 120819A; 8.5 Pharmacological profile of SR 120819A in vivo; 8.6 Conclusion; Acknowledgements; References; Chapter 9. BIBP 3226, a potent and selective neuropeptide Y Yl receptor antagonist. Structure-activity studies and localization of the human Yl receptor binding site; 9.1 Introduction; 9.2 The design of the Yl-receptor antagonist BIBP 3226
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9.3 The first structure-activity relationships
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English
Additional Edition:
ISBN 0-12-304990-3
Language:
English
