Kooperativer Bibliotheksverbund

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Format: 1 online resource (634 p.)

ISBN: 1-283-62614-4 , 0-12-387830-6 , 9786613938596

Content: This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. 〈b

Note: Description based upon print version of record. , Front Cover; Genetics of Bone Biology and Skeletal Disease; Copyright Page; Contents; Preface; List of Contributors; I. General Background to Bone Biology; 1 Biology of Bone and Cartilage; I. Introduction; II. Osteoclasts; Regulation of Osteoclast Formation: The RANKL-RANK-OPG System; Transcription Factor Regulation of Osteoclastogenesis; RANKL/RANK Downstream Signaling; Regulation of Osteoclast Activation; Negative Regulation of Osteoclast Formation and Function; Osteoclast Apoptosis; III. Osteoblasts; Regulation of Osteoblast Formation; Runx2; Osterix (Osx); Bone Morphogenetic Proteins , Wingless (Wnt)Notch; Regulation of Matrix Proteins; Activating Transcription Factor (ATF) and Activator Protein 1 (AP-1); Type I Collagen Modification; Regulation of Osteoblast Communication; Ephrins; Semaphorins; Neural Regulation of Bone Formation; Negative Regulation of OB Function; IV. Cartilage; Chondrocytes; Endochondral Ossification; Endochondral Ossification in the Adult Skeleton; Formation of the Articular Cartilages; Cartilage Degeneration; References; 2 Overview of Bone Structure and Strength; I. Introduction; II. Bone Biomechanics and the Determinants of Whole Bone Strength , Structural vs Material Properties of BoneMechanical Properties of Bone Tissue Depend on Loading Direction; Determinants of Biomechanical Properties of Trabecular and Cortical Bone; III. Contribution of Bone Geometry to Bone Strength; Age-Related Changes in Bone Size and Shape; IV. Age-Related Changes in Trabecular and Cortical Bone Microarchitecture; V. Contribution of Bone Microarchitecture to Bone Strength; Trabecular Microarchitecture; Age-Related Changes in Cortical and Trabecular Bone Material Properties; Contribution of Bone Structure to Vertebral Strength , Contribution of Bone Structure to Proximal Femoral StrengthVI. Contribution of Bone Structure to Fracture Risk in Humans; VII. Summary; References; 3 Overview of Joint and Cartilage Biology; I. Introduction; II. Joint Development; Joint Development as Part of Skeletal Development; Joint Site Determination; What Happens in the Joint Interzone?; Joint Cavitation; The Differentiation of the Articular Cartilage and Other Joint Structures; Integration of the Joints with the Skeleton and Joint Shape Morphogenesis; III. Joint Anatomy; The Articular Cartilage; Collagens; Proteoglycans , Non-Collagenous Matrix ProteinsOrganization of the Articular Cartilage; Soft Tissues of the Joint; The Enthesis; IV. Joint Homeostasis; V. Joint Disease; Rheumatoid Arthritis; Spondyloarthritis; Osteoarthritis; VI. Joint Repair; Tissue Repair by Enhancing the Endogenous Healing Response; Joint Resurfacing by Tissue Engineering; References; 4 Integrating Endocrine and Paracrine Influences on Bone: Lessons from Parathyroid Hormone and Parathyroid Hormone-related Protein; I. Bone Remodeling and Modeling; II. Parathyroid Hormone (PTH) and Parathyroid Hormone-Related Protein (PTHrP) , III. PTHrP in Bone: Production in Osteoblasts , English

Additional Edition: ISBN 0-12-387829-2

Language: English