Kooperativer Bibliotheksverbund

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Format: 1 online resource (220 pages)

Edition: First edition.

ISBN: 0-12-814611-7 , 0-12-814610-9

Content: Molecular Pathology and the Dynamics of Disease bridges the basic science of, and primary clinical literature on, human disease. Topics covered include several major disease areas, such as inflammation and host response, vascular disease, obesity, weight regulation and appetite, cancer biology, drug development, and gene- and cell-based therapeutics that are all presented in a way that emphasizes the interplay between clinical care and investigation. As new technologies and techniques are constantly changing and laboratory scientists plays a critical role in validating data used by clinicians in diagnosing patients, this book provides a timely guide that includes a clinical, research and theory perspective.--

Note: Front Cover -- Molecular Pathology and the Dynamics of Disease -- Copyright Page -- Dedication -- Contents -- Preface -- 1 Molecular Pathology Introduction and Research Review -- Pathogenesis Overview and Review -- Cellular Pathogenesis -- Local Replication and Local Spread -- Dissemination in the Bloodstream -- Dissemination in Nerves -- Incubation Period -- Multiplication in Target Organs -- Shedding of Virus -- Congenital Infections -- NK Cells in Hepatitis C Virus Infection -- Conclusions -- References -- Further Reading -- 2 Challenges in Molecular Pathology -- General Overview of Molecular Applications in Pathology -- Technical Obstacles for the Molecular Diagnostic Industry and in the Pathology Laboratory -- Technological Challenges in molecular assays -- Mutation Detection in Precision Medicine -- Detection of Chromosomal Rearrangements: In Situ Hybridization -- Validation of Comprehensive Molecular Assays -- Quality Management Program -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- References -- Further Reading -- 3 Review of Clinical Human Medical Genetics -- Deoxyribonucleic Acid (DNA) -- Overview -- Types of DNAs -- Overview -- Context of Clinical Human Genetics -- Approved Molecular Medicine Assays in Pathology -- SNPs are Influential Single Nucleotide Polymorphisms -- Deletions and Insertions in Human DNA -- Short Tandem Repeats are Observed in Certain Types of Cancer -- Chromosome Rearrangements -- Copy Number Variation -- Somatic Mutations Versus Germline Mutations. , Over the Counter Genetic Testing -- SNPs and Functional Polymorphisms -- Insights Into the Mechanisms for Disease -- References -- Further Reading -- 4 Molecular Medicine in Action -- Grossing Procedures -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Specimen Adequacy -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Specimen Collection Instructions -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Immunohistochemistry and HPV In Situ Procedures -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Kwik-Diff Staining. , 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Non-GYN Staining -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Gram Stain Method: Hucker's Modification -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Gomori's Trichrome Stain -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Acid-Fast Bacilli Stain for Mycobacteria -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements. , 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- Destaining Procedure -- 1.0 Principle/Indications -- 2.0 Specimen Requirement/Types -- 3.0 Supplies/Equipment/Reagents -- 4.0 Instrumentation -- 5.0 Calibration -- 6.0 Quality Control -- 7.0 Environmental Requirements -- 8.0 Operating Procedure -- 9.0 Maintenance -- 10.0 Calculations -- 11.0 Result Reporting -- 12.0 Procedural Notes -- 13.0 Limitations -- 14.0 Instrumentation Downtime -- 15.0 References -- 5 Mechanisms of Disease -- NK Cells in CMV Infection -- NK Cells in HIV-1 Infection -- References -- Further Reading -- Index -- Back Cover.

Language: English