UID:
almahu_9949460423302882
Edition:
1st ed.
ISBN:
9789175190150
Content:
This dissertation investigates the intercellular transmission of proteins associated with neurodegenerative diseases, specifically α-synuclein, amyloid-β, and TDP-43. The research explores how these proteins propagate in a prion-like manner, leading to diseases such as Alzheimer's, Parkinson's, and ALS. The study identifies mechanisms, such as the role of gap junction proteins like connexin 32, that facilitate the uptake and spread of toxic protein oligomers between cells. The findings highlight potential targets for therapeutic intervention by understanding the early effects and pathways through which these proteins cause cellular toxicity. This work is relevant for researchers and healthcare professionals focused on neurodegenerative disease progression and treatment.
Note:
ABSTRACT -- POPULAR SCIENTIFIC SUMMARY -- POPULÄRVETENSKAPLIG SAMMANFATTNING -- LIST OF INCLUDED PAPERS -- LIST OF PAPERS NOT INCLUDED -- ABBREVIATIONS -- INTRODUCTION -- AIMS -- METHODOLOGY -- RESULTS & DISCUSSION -- CONCLUDING REMARKS -- ACKNOWLEDGEMENTS -- REFERENCES -- Papers
Language:
English
