UID:
almafu_9961256481702883
Format:
1 online resource (xvii, 1340 pages) :
,
illustrations (some color)
Edition:
Fourth edition.
ISBN:
9781119876007
,
9781119875994
,
1119875994
,
9781119875987
,
1119875986
,
1119876001
Uniform Title:
Pancreas (Beger)
Content:
"The fourth edition of The Pancreas presents the most comprehensive and latest knowledge about the genetic and molecular biological basis of embryology, anatomy, physiology, pathophysiology, and pathology for all disorders of the pancreas. Compared to the first edition, published in 1998, the fourth edition contains three newly addressed diseases of the pancreas: autoimmune pancreatitis, benign and premalignant cystic neoplasms, and neuroendocrine tumors. The understanding of the functions and dysfunctions of the exocrine and endocrine pancreas is derived from increasingly profound molecular biological data on the actions of compounds in subcellular compartments and intracellular transcription pathways. In the respective chapters, the presentation of the inflammatory (acute or chronic) and oncological diseases (benign, premalignant, or advanced cancer) is based on molecular biological understanding of pathomorphological processes and clinical phenomena. In clinical pancreatology, new and improved technical devices enable the gastroenterologist and the gastrointestinal surgeon to identify lesions by high-resolution imaging techniques, imaging of metabolic processes, and intrapancreatic ductal morphologic processes. The molecular profiling of pancreatic ductal adenocarcinoma has provided a deeper understanding of the genomic alterations that drive pancreatic ductal adenocarcinoma, including driver genes, actionable mutations, copy number alterations, patterns of genomic aberrations, structural variations, and mutational signatures. These findings have transformed our biological genomic understanding, but are still of limited clinical utility. Significant progress has been made in understanding the molecular pathogenesis of pancreatic cancer and identification of various molecular subtypes. However, this improved understanding has unfortunately not yet led to relevant progress for the patient's cure, although survival gain after radical cancer resection in addition with adjuvant chemotherapy is significant for selected groups of patients"--
Additional Edition:
Print version: Pancreas (Beger) Pancreas Hoboken, NJ : Wiley, 2023 ISBN 9781119875970
Language:
English
DOI:
10.1002/9781119876007
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781119876007
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781119876007
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781119876007
