Kooperativer Bibliotheksverbund

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Format: 1 online resource (261 p.)

ISBN: 1-281-02110-5 , 9786611021108 , 0-08-052190-8

Content: Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information.* Provides detailed discussion of the genetic mechanisms that result in the ge

Note: Description based upon print version of record. , Front Cover; Genetic Recombination in Cancer; Copyright Page; Contents; Preface; Abbreviations; Chapter 1. Introduction; Chapter 2. Genetic integrity, DNA repair and recombination; Base excision and nucleotide excision repair system; RAD genes and their operation in DNA replication checkpoint; DNA recombination repair pathway; VDJ recombination, the immune system and haematological malignancy; SET domain proteins in genetic transcription, growth regulation and myeloma; Ku protein in cell function; Chapter 3. Replication error (RER) and genetic instability , Microsatellite instability and cancer progressionEffects of microsatellite instability on p53 and growth factor gene expression; Influence of microsatellite instability on invasive behaviour of tumours; Microsatellite instability and metastasis suppressor nm23 gene abnormalities; Chromosomal fragile sites and the RER phenotype; Sister chromatid recombination and fragile sites; Microsatellite instability and sister chromatid recombination; Genomic stability and chromosome structural dynamics; Chapter 4. DNA repeats, genetic recombination and the pathogenesis of genetic disorders , CAG repeat expansion and genetic instabilityMicrosatellite dinucleotide repeats in insulin-dependent diabetes mellitus and autoimmune thyroid disease; Alu repeats in genetic recombination; LINE repeats in genetic rearrangement; Cognate elements associated with recombination; Chapter 5. Chromosomal recombination in cancer; Karyotypic abnormalities in cancer; DNA aneuploidy and cancer progression; DNA ploidy, cell proliferation and growth factor expression; Association of DNA ploidy with p53 abnormalities; Chapter 6. Chromosomal translocation and its phenotypic effects , Chromosomal translocation and signal transductionChromosomal translocation and the dynamics of cell population expansion in cancer; The PI-3 kinase/Akt pathway of signal transduction in cell proliferation, apoptosis and differentiation; Chromosomal translocation and genetic transcription; Chromosomal translocation, fusion proteins and tumour vascularisation; Chromosomal translocations, fusion proteins and immunity; The association of chromosomal translocation with fragile sites; Chromosomal fragility, genetic loss and tumour suppressor genes , Gene amplification and its relationship to genetic instabilityChromosomal fragility and micronuclei; Chapter 7. DNA methylation and genetic instability; DNA methylation in normal and neoplastic development; Abnormal DNA methylation in ICF and Rett syndromes; DNA methylation and genetic instability; The CpG Island Methylator Phenotype (CIMP); Influence of DNA methylation on recombination; Methylation-associated chromosomal recombination and genetic transcription in childhood leukaemias; The dynamics of histone acetylation in cell differentiation, cell proliferation and neoplasia , The effects of p53 methylation on chromosome stability , English

Additional Edition: ISBN 0-12-639881-X

Language: English