UID:
edoccha_9958129193702883
Format:
1 online resource (736 pages) :
,
illustrations
Edition:
2nd edition
ISBN:
1-283-54009-6
,
9780080513362
Content:
"The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style."
Note:
"Revised edition."
,
Front Cover; The Organic Chemistry of Enzyme-Catalyzed Reactions; Copyright Page; Table of Contents; Preface; About the Author; Chapter 1. Enzymes as Catalysts; I. What Are Enzymes, and How Do They Work?; II. Mechanisms of Enzyme Catalysis; III. Enzyme Catalysis in Organic Media; IV Enzyme Nomenclature; V. Epilogue; References; Chapter 2. Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation; I. Hydrolysis Reactions; II. Aminations; III. Phosphorylations: Transfers of Phosphate and Phosphate Esters to Water or Other Acceptors; References; Chapter 3. Reduction and Oxidation
,
I. GeneralII. Redox without a Coenzyme; III. Redox Reactions That Require Coenzymes; References; Chapter 4. Monooxygenation; I. General; II. Flavin-Dependent Hydroxylases; III. Pterin-Dependent Hydroxylases; IV. Heme-Dependent Monooxygenases; V. Nonheme Iron Oxygenation; VI. Copper-Dependent Oxygenation; References; Chapter 5. Dioxygenation; I. General; II. Intramolecular Dioxygenases; III. Intermolecular Dioxygenases; References; Chapter 6. Substitutions; I. SN1; II. SN1/SN2; III. SN2; IV SN2'; V. SNAr: Nucleophilic Aromatic Substitution; VI. Electrophilic Substitution (Addition/Elimination)
,
VII. Electrophilic Aromatic SubstitutionReferences; References; Chapter 7. Carboxylations; I. General Concepts; II. Carbon Dioxide as the Carboxylating Agent; III. Bicarbonate as the Carboxylating Agent; Chapter 8. Decarboxylation; I. General; II. β-Keto Acids; III. β-Hydroxy Acids; IV. α-Keto Acids; V. Amino Acids; VI. Other Substrates; References; Chapter 9. Isomerizations; I. General; II. [1,1]-Hydrogen Shift; III. [1,2]-Hydrogen Shift; IV. [1,3]-Hydrogen Shift; V. Cis/Trans Isomerizations; VI. Phosphate Isomerization; References; Chapter 10. Eliminations and Additions
,
I. Anti Eliminations and AdditionsII. Syn Eliminations and Additions; References; Chapter 11. Aldol and Claisen Reactions and Retroreactions; I. Aldol Reactions; II. Claisen Reactions; Chapter 12. Formylations, Hydroxymethylations, and Methylations; I. Tetrahydrofolate-Dependent Enzymes: The Transfer of One-Carbon Units; II. S-Adenosylmethionine-Dependent Enzymes: The Transfer of Methyl Groups; References; Chapter 13. Rearrangements; I. Pericyclic Reactions; II. Rearrangements That Proceed via Carbenium Ion Intermediates; III. Rearrangements That Proceed via Radical Intermediates
,
IV. EpilogueReferences; Appendix I: Enzyme Kinetics; I. Substrate Kinetics; II. Kinetics of Enzyme Inhibition; III. Substrate Inhibition; IV. Nonproductive Binding; V. Competing Substrates; VI. Multisubstrate Systems; VII. Allosterism and Cooperativity; References; Appendix II: Problems and Solutions; I. Problems; II. Solutions to Problems; Index
Additional Edition:
Print version: ISBN 9780126437317
Additional Edition:
Print version: ISBN 0126437319
Language:
English
