Kooperativer Bibliotheksverbund

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Format: 1 online resource

ISBN: 0-12-815973-1

Note: Includes index. , Front Cover -- Pathology -- Copyright Page -- Contents -- List of contributors -- Preface -- I. Oxidative Stress and Pathology -- 1 Free radicals: what they are and what they do -- List of abbreviations -- Introduction -- Free radicals: general characteristics -- Oxidative chain reactions -- Selected free and nonfree radicals: characteristics and behavior -- Superoxide radical (O2−) -- Hydrogen peroxide (H2O2) -- Hydroxyl radical (OH) -- Alkoxyl (RO) and peroxyl (ROO) radicals -- Singlet oxygen (1O2) -- Ozone (O3) -- Hypochlorous acid (HOCl) -- Nitric oxide (nitrogen monoxide -- NO) -- Other reactive nitrogen species -- Sources of free radicals -- Mitochondria -- Peroxisomes -- Endoplasmic reticulum -- Oxidative stress -- Proteins -- Deoxyribonucleic acid -- Ribonucleic acid -- Lipids -- Free radicals in health and disease -- Conclusion -- Applications to other areas of pathology -- Summary points -- Acknowledgment -- References -- 2 Oxidative stress in pathologies of male reproductive disorders -- List of abbreviations -- Introduction -- Redox biology in male reproduction -- Oxidative stress and male factor infertility -- Sources of reactive oxygen species in the male reproductive tract -- Endogenous reactive oxygen species and antioxidants -- Leukocytes -- Immature spermatozoa -- Exogenous reactive oxygen species and antioxidants -- Radiation -- Lifestyle factors -- Toxins -- Oxidative stress in male reproductive pathology -- Genitourinary tract infections -- Systemic infections -- Autoimmune/inflammatory conditions -- Cryptorchidism and varicocele -- Other chronic diseases -- Oxidative stress in erectile dysfunction -- Oxidative stress in hypogonadism -- Mechanisms of oxidative stress-induced reproductive dysfunction -- Lipid peroxidation -- DNA integrity -- Mitochondrial dysfunction -- Apoptosis. , Assessment of oxidative stress in the male reproductive system -- Use of antioxidants in male infertility treatment -- Nutritional sources -- Supplementary antioxidants -- Phytonutrients -- Antioxidant paradox and reductive stress -- Applications to other areas of pathology -- Conclusion -- Summary points -- References -- 3 Oxidative stress and diabetic retinopathy -- List of abbreviations -- Introduction -- Molecular mechanisms of diabetic retinopathy -- Oxidative stress and reactive oxygen species -- Nonenzymatic production of reactive oxygen species -- Enzymatic production of reactive oxygen species -- Relationship between oxidative stress and other biochemical pathways -- Enhanced polyol pathway -- Increased accumulation of advanced glycation end products -- Activation of protein kinase C -- Activation of hexosamine pathway -- Oxidative stress and structural and functional alterations in diabetic retinopathy -- Basement membrane thickening -- Alterations in retinal microvasculature -- Apoptosis of retinal cells -- Oxidative stress-related epigenetic modifications in diabetic retinopathy -- DNA methylation -- Histone modification -- MicroRNAs -- Sirtuin proteins -- Conclusion -- Summary points -- References -- 4 Pathological bases of oxidative stress in the development of cardiovascular diseases -- List of abbreviations -- Introduction -- Mitochondrial production of reactive species -- Role of oxidative stress in cardiovascular disease -- Ischemia and reperfusion -- Hyperlipidemia and atherosclerosis -- Hypertension -- Nicotinamide adenine dinucleotide phosphate oxidase -- Xanthine oxidase -- Uncoupled endothelial nitric oxide synthase -- Mitochondrial dysfunction in hypertension -- Inflammation -- Applications to other areas of pathology -- Summary points -- References. , 5 Pathological association between oxidative stress and chronic obstructive pulmonary disease -- List of abbreviations -- Introduction -- Chronic obstructive pulmonary disease overview -- Oxidative stress -- The role of oxidative stress in chronic obstructive pulmonary disease pathogenesis -- Environmental reactive species and chronic obstructive pulmonary disease -- Cellular reactive species and chronic obstructive pulmonary disease -- Cellular reactive oxygen species -- Cellular reactive nitrogen species -- Applications to other areas of pathology -- Summary points -- References -- 6 Oxidative stress in sickle cell disease and emerging roles for antioxidants in treatment strategies -- List of abbreviations -- Introduction -- Epidemiology and global burden of sickle cell disease -- Clinical manifestations of sickle cell disease and treatment options -- Pathophysiology of sickle cell disease -- Oxidative stress in sickle cell disease pathogenesis -- The physiology of red blood cells in coping with oxidative stress -- The pathology of sickle red blood cells due to increased oxidative stress -- Clinical consequences of oxidative stress in sickle cell disease -- Agents targeting antioxidant defense in sickle cell disease patients -- Future prospects -- Applications to other areas of pathology -- Summary points -- References -- 7 Nrf2 and oxidative stress -- List of abbreviations -- Introduction -- Nrf2: function -- Nrf2: relation with disease -- Dietary compounds that could activate the Nrf2 and Nrf2/ARE pathway -- Applications to other areas of pathology -- Summary points -- References -- 8 Redox signaling and antioxidant defense in pathogenic microorganisms: a link to disease and putative therapy -- List of abbreviations -- Introduction -- Oxidative stress: a short historical overview -- Redox signaling: definition and mechanisms -- A paradox. , Redox signaling as a determinant for pathogen elimination in the context of oxidative stress -- Redox signaling as a determinant for pathogen thriving in the context of oxidative stress -- The perception shift -- The intriguing dual role of antioxidants -- Association of reactive species and antioxidants with putative therapy against pathogens -- Future perspectives in therapy against pathogens -- Applications to other areas of pathology -- Summary points -- References -- 9 Paraoxonase 1 as antioxidant enzyme in children -- List of abbreviations -- Introduction -- Paraoxonase 1: general characteristics -- Paraoxonase 1 in pediatric populations -- Conclusion -- Applications to other areas of pathology -- Summary points -- References -- 10 The regulation of intracellular redox homeostasis in cancer progression and its therapy -- List of abbreviations -- Introduction -- Sources of intracellular ROS -- Regulation of intracellular ROS production -- Regulation in catabolism of intracellular ROS -- Role of oxidative stress in carcinogenesis -- Modulation of mitogen activated protein kinase -- Modulation of Keap1-Nrf2 pathway -- Modulation of FOXO transcription factors and p53 -- Modulation of NF-κB -- Modulation of STAT family proteins -- Targeting oxidative stress in cancer therapeutics -- Antioxidant-mediated therapeutic strategy -- Upregulation of intracellular ROS levels -- Target antioxidants to decrease ROS scavenging capacity -- Conclusion -- Applications to other areas of pathology -- Summary points -- References -- II. Antioxidants and Pathology -- 11 Antioxidant and chelator cocktails to prevent oxidative stress under iron-overload conditions -- List of abbreviations -- Introduction -- The effects of the combination of an iron chelator with vitamin c on oxidative stress and iron status in iron-overloaded co... , The effects of a combination of an iron chelator with silymarin on oxidative stress and iron status in iron-overloaded cond... -- The effects of a combination of an iron chelator with N-acetylcysteine on oxidative stress and iron status in iron-overload... -- The effects of a combination of an iron chelator with vitamin E on oxidative stress and iron status in iron-overloaded cond... -- The effects of the combination of an iron chelator with curcumin or idebenone on oxidative stress and iron status in iron-o... -- The effects of a combination of an iron chelator with other antioxidants and multiantioxidants on oxidative stress and iron... -- Applications to other areas of pathology -- Summary points -- Acknowledgments -- References -- 12 Açaí (Euterpe oleracea Martius) as an antioxidant -- List of abbreviations -- Introduction -- Açaí antioxidants -- Antioxidant activity of açaí: in vitro bioassays -- Antioxidant activity of açaí: animal model assays -- Antioxidant activity of açaí: human studies -- Applications to other areas of pathology -- Summary points -- References -- 13 Amaryllidaceae alkaloids and neuronal cell protection -- List of abbreviations -- Introduction -- Neurodegenerative diseases and neuronal cell damage -- Oxidative stress related with neuronal cell damage -- Current pharmacotherapy of dementias (mainly Alzheimer's disease) -- Galanthamine, the only drug of natural origin for the symptomatic treatment of Alzheimer's disease -- Amaryllidaceae alkaloids -- Efficacy of amaryllidaceae alkaloids in oxidative stress and neuronal cell damage -- Conclusion -- Applications to other areas of pathology -- Summary points -- Acknowledgments -- References -- 14 Anthocyanins and anthocyanin-rich food as antioxidants in bone pathology -- List of abbreviations -- Introduction -- Oxidative stress and inflammation. , Bone physiology and pathology under oxidative stress.

Additional Edition: ISBN 0-12-815972-3

Language: English