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Format: 1 online resource (535 pages)

ISBN: 3-031-08309-1

Note: Intro -- Preface on the Current Trends in Cardiovascular Signaling in Health and Disease -- Calcium- and Stress-Dependent Signaling in Cardiac Myocytes -- Reactive Oxygen Species and Lipid Signaling in Cardiac Myocytes -- Inflammatory Signaling, Fibrosis, and Cardiac Function -- Neural Regulation of Cardiac Rhythm -- Reverse Cholesterol Transport in Atherosclerotic Cardiovascular Disease -- Progression of the Atherosclerotic Plaque Regression -- Role of Bioactive Lipid, Phosphatidic Acid in Statin-Induced Myotoxicity -- Cell-to-Cell Communication in the Vascular Endothelium -- The Bioactive Phospholipid, Lysophosphatidic Acid Regulates Vascular Endothelial Barrier Integrity -- Role of Lipid Mediators in Regulation of Vascular Endothelial Barrier Integrity and Function -- Role of Iron in Diabetic Vascular Endothelial Dysfunction -- Acknowledgments -- Contents -- Authors Biography -- Part I: Cardiac Signaling -- Calcium-Dependent Signaling in Cardiac Myocytes -- Introduction -- Physiology -- Pathophysiology -- Heart Failure -- Arrhythmias -- Ca-Dependent CaMKII Signaling in the Cardiac Myocyte -- Background -- Ca-Dependent CaMKII Signaling in Cardiac Myocyte Function and Disease -- CaMKII Structure and Ca-Dependent Activation -- Posttranslational Modifications of CaMKII as Novel Mechanisms of Cardiac Disease -- Cardiac Myocyte Remodeling and Ultrastructural Change -- Background -- Ultrastructural (T-Tubule) Remodeling -- RyR Remodeling -- Consequence of Structural Remodeling on Spatiotemporal Factors of Ca Release -- Potential Treatments -- Conclusions and Research Frontiers -- Spatial and Temporal Heterogeneity of Ca-Dependent Signaling -- Considerations for Therapy -- References -- Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes -- Introduction -- Calcium Signaling in Cardiomyocytes. , Calcium Signaling Microdomains in Cardiomyocytes -- TT/jSR Microdomains in Systolic and Diastolic Calcium Handling -- Organization of cBIN1 and JP2 Microdomains at TT/jSR Membrane -- Calcium Signaling at the cBIN1 and Other TT/jSR Microdomains -- TT/jSR Microdomains, Calcium Signaling, and Heart Failure -- Ankyrin-Spectrin Microdomains in Calcium Signaling -- Organization of Ankyrin B-βII Spectrin Microdomains -- Ankyrin-Spectrin Microdomain-Regulated Calcium Signaling -- Ankyrin-Spectrin Microdomains in Cardiovascular Diseases -- Caveolae Microdomains in Calcium Signaling and Stress Response -- Organization of Caveolae Microdomains in Cardiomyocytes -- Caveolae-Related Organization of Calcium Signaling -- Caveolae, Calcium Signaling, and Disease -- Conclusions and Future Perspectives -- References -- Stress Kinase Signaling in Cardiac Myocytes -- Introduction -- Stress Kinase MAPK Signaling in the Heart -- JNK -- P38 -- ERK -- MAPKs and Calcium Homeostasis in Myocytes -- Normal and Abnormal Calcium (Ca2+) Signaling in Myocytes -- MAPKs in Stress-Evoked Ca2+ Mishandling in Myocytes -- MAPKs and Ca Handling Proteins in Myocytes -- MAPKs and Molecular Remodeling in Myocytes -- MAPKs and Gene Regulation in Myocytes -- MAPKs and Apoptotic Signaling Pathways in Stress-Exposed Myocytes -- JNK and Apoptotic Signaling Pathways in Myocytes -- p38 and Apoptotic Signaling Pathways in Myocytes -- ERK and Apoptotic Signaling Pathways in Myocytes -- Dynamic Relationships of MAPKs in Pathological Cardiac Remodeling in Stressed Hearts -- MAPKs and Therapeutic Potentials -- References -- Intracellular Cardiac Signaling Pathways Altered by Cancer Therapies -- Part I: Introduction -- Tyrosine Kinase Inhibitor Therapy -- Immune Checkpoint Therapy -- CAR T-Cell Therapy -- Part II: Tyrosine Kinases Inhibitor Therapy -- Tyrosine Kinase Signaling. , Abnormal Tyrosine Kinase Activity and Signaling in Cancer -- Tyrosine Kinase Inhibitors -- Tyrosine Kinase Receptors and Cardiomyopathy -- VEGF/VEGFR Signaling -- PDGF/ PDGFR Signaling -- c-KIT Signaling -- TKI-Induced Cardiovascular Dysfunction -- Hypertension -- Arrhythmias -- TKIs and Ion Homeostasis -- TKI-Mediated Potassium Ion Channel Dysfunction -- TKI Dysregulation of Calcium-Mediated Signaling -- TKIs and Sodium Channels: An Unexplored Territory -- TKIs and Heart Failure -- TKIs and Thromboembolism -- Monitoring and Treatment of TKI-Induced Cardiotoxicity -- Part III: Immune Checkpoint Inhibitors -- T-Cell Activation and Regulation -- Mechanisms of ICI-Mediated Cardiac Disorders -- Arrhythmias -- Myocarditis and Pericarditis -- Heart Failure -- Monitoring and Treatment of ICI-Associated Cardiotoxicity -- Part IV: CAR T-Cell Immunotherapy -- CAR T-Cell Mechanism of Action -- Proposed Mechanisms of Cardiotoxicity in CAR T-Cell Therapy -- JAK/STAT Signaling Pathway -- IL-6 -- TNFα -- Interleukin 1 -- Off-Target Affects -- Monitoring of CAR T-Cell Associated Cardiotoxicity -- Current and Proposed Treatments for CAR T-Cell-Induced Cardiotoxicity -- References -- Protein Phosphatase Signaling in Cardiac Myocytes -- Introduction -- The Kinase-Phosphatase Axis -- Protein Phosphatase Families and Genetics -- Localization and Binding Partners of Protein Phosphatases -- Mouse Models -- Protein Phosphatases in Cardiovascular Disease -- PP1 in Cardiovascular Disease -- PP2A in Cardiovascular Disease -- PP2B in Cardiovascular Disease -- Conclusions and Future Directions -- References -- Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function -- Mitochondrial Dynamics: Fusion and Fission Events -- Diabetes-Related Cardiac Ischemia and Reperfusion Injury -- Diabetes-Related Cardiac Chronic Remodeling, Hypertrophy, and Failure. , Metabolic Control of Mitochondrial Dynamics: The Role of AMPK -- Concluding Remarks -- References -- NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes -- Introduction -- Materials and Methods -- Chemicals, H9c2 Cardiomyocytes, and Cell Culture Supplies -- Synthesis of Cholesterol Secoaldehyde -- Cell Culture and Treatments -- Cell Proliferation and Metabolism -- Trypan Blue Exclusion Assay -- Measurement of Intracellular Peroxides -- Measurement of Hydrogen Peroxide -- Thiobarbituric Acid-Reactive Substances (TBARs) -- Measurement of Reduced Glutathione Levels -- Assay of Superoxide Dismutase Activity -- Measurement of Mitochondrial Transmembrane Potential -- Western Blot Analysis -- Statistical Analysis -- Results -- Apocynin Exacerbates While DPI Reduces the ChSeco-Induced Cytotoxic Response in H9c2 Cardiomyocytes -- NOS Inhibitors Attenuate the Formation of Peroxide or Peroxide-Like Substances in ChSeco-Exposed H9c2 Cardiomyocytes -- Apocynin Lowers the GSH Levels in ChSeco-Exposed Cardiomyocytes -- Apocynin But Not DPI Enhances the ChSeco-Induced Activation of SOD Activity in H9c2 Cardiomyocytes -- Apocynin and DPI Pretreatment in H9c2 Cardiomyocytes Reduces TBARs Formed in Response to the Exposure of ChSeco -- ChSeco-Induced Loss in Mitochondrial Transmembrane Potential Is Reversed by Pretreatments with Apocynin and DPI -- ChSeco-Induced Overexpression of pp38 and pSAPK in H9c2 Cardiomyocytes Is Mitigated by Pretreatments with Apo and DPI -- Discussion -- Conclusion -- References -- Lipid Mediators in Cardiovascular Physiology and Disease -- Introduction -- Lipid Mediators -- Oxylipins -- PUFA Reservoirs -- Oxylipin Synthesis -- Cyclooxygenase-Derived Oxylipins -- Lipoxygenase-Derived Oxylipins -- Cytochrome P450-Derived Oxylipins -- Conclusion and Future Perspectives. , References -- Cardiac Inflammasome and Arrhythmia -- Introduction -- Cardiac Electrophysiology -- Pathophysiology of AF -- Inflammasome Signaling -- Cardiac Inflammasome Signaling and Arrhythmogenesis -- Inflammasome-Mediated Pathogenesis of AF -- Nlrp3 Inflammasome Links AF Risk Factors to Atrial Arrhythmogenesis -- Nodal Signaling Points of Nlrp3 Activation -- Therapeutic Potential of Targeting the Cardiac NLRP3 Inflammasome -- Summary and Future Perspectives -- References -- Myocardial Fibrosis: Cell Signaling and In Vitro Modeling -- Introduction -- The Normal Myocardium -- Myocardial Fibrosis -- Modeling Myocardial Fibrosis -- Mechanotransduction -- Cell-Cell and Cell-ECM Interactions -- Pro-Fibrotic Soluble Mediators -- Conclusion -- References -- Neural Regulation of Cardiac Rhythm -- Introduction -- Neuronal Anatomy and Organization -- Cardiac Responses to Neurochemicals -- Adrenergic Signaling -- Muscarinic Signaling -- Co-transmission -- In vitro Models to Study Neural Regulation of Cardiac Rhythm -- Co-cultures -- Isolated Heart and Tissue Preparations -- Conclusions -- References -- Part II: Vascular Signaling -- Mechanisms of Lipoproteins and Reverse Cholesterol Transport in Atherosclerotic Cardiovascular Disease -- Introduction -- Lipoproteins Involved in Cholesterol Transport -- The Reverse Cholesterol Transport Pathway -- Mechanisms of Diseases Associated with Atherosclerotic CVD -- Genetic Predisposition to Cholesterol-Driven Cardiovascular Disease -- Therapeutic Approaches Targeting Lipoproteins -- LDL-C-Targeted Therapies -- HDL-C-Targeted Therapies -- References -- Atherosclerotic Plaque Regression: Future Perspective -- Introduction -- Development of Atherosclerotic Plaque and Formation of Primary Oxidation Products -- Role of Protein Carbonyls in Atherosclerotic Plaque Progression -- Factors Affecting Plaque Regression. , Increasing HDL Cholesterol.

Additional Edition: Print version: Parinandi, Narasimham L. Cardiovascular Signaling in Health and Disease Cham : Springer International Publishing AG,c2022 ISBN 9783031083082

Language: English

Keywords: Llibres electrònics