Tetrahedron Letters, 2000, Vol.41(52), pp.10159-10162
The lipase TL®-mediated kinetic resolution of (±)-benzoin ( 1 ) proceeded to give the corresponding optically pure benzoin ( R )- 1 . On the other hand, ( S )-benzoin- O -acetate ( 5 ) could be hydrolyzed without epimerization to give ( S )-benzoin ( S )- 1 , under alkaline conditions. Further, ( R )- 1 was converted to (1 R ,2 S )-2-amino-1,2-diphenylethanol (99:1 er) according to the procedure reported previously.
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