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  • 1
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 01 November 2012, Vol.22(21), pp.6766-6769
    Description: We investigated several 2-phenylquinazolines with different substitutions at position 4 for their BCRP inhibition. Compounds with phenyl ring attached via an amine-containing linker at position 4 were found to be potent inhibitors of BCRP. In general compounds with substitution of phenyl ring at position 4 were found to have higher inhibitory effect, compound being the most potent and selective towards BCRP.
    Keywords: Bcrp ; Inhibitors ; Multidrug Resistance ; Quinazolines ; Hoechst 33342 ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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