Format:
Online-Ressource (digital)
ISBN:
9780387767154
Series Statement:
Advances in Experimental Medicine and Biology 621
Content:
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
Content:
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring. The journey starts with a description of the classical guidance signals such as the netrins, the semaphorins, the ephrins or the Slit family. The question of the exact definition of a guidance signal is addressed in a chapter which discusses whether neurotrophic factors can be considered as guidance cues. This complex question is also considered in a chapter presenting the role of adhesion molecules during axon guidance and the report of compelling evidence for a guidance effect of neurotransmitters. The diversity of the molecular cues used by growth cones to reach their targets is finally illustrated in a chapter describing the unexpected role of morphogenes as direct guidance signals.
Note:
Includes bibliographical references and index
,
CONTENTS; PREFACE; 1. MOLECULAR MECHANISMS OF AXONAL GROWTH; Introduction; The Neuronal Growth Cone and its Cytoskeletal Organization; Mechanisms of Axonal Elongation; Regulation of the Cytoskeleton by Extracellular Cues, Role of Rho-GTPases; Growth Cone of Regenerating Axons; 2. NETRINS AND THEIR RECEPTORS; Introduction; Netrin Structure; Functional Roles for Netrins during Nervous System Development; Netrin Signal Transduction; Netrin in the Adult Nervous System; Conclusion and Perspectives; 3.Eph RECEPTORS AND EPHRIN LIGANDS IN AXON GUIDANCE; Introduction; Molecular Structure
,
Mechanisms of Signal TransductionFunctional Implications during Nervous System Development; Conclusion and Perspectives; 4. ROLE OF SEMAPHORINS DURING AXON GROWTH AND GUIDANCE; Introduction; Functional Roles of Semaphorins during Axon Guidance; Receptors of Secreted-Semaphorins: The Neuropilins; Receptors of Transmembrane-Semaphorins: The Plexin Family; Other Receptors Associated with Semaphorin Signaling; Intracellular Signal Transduction; Conclusion; 5. SLITS AND THEIR RECEPTORS; Introduction; Robo Partners; Molecular Control of Slit and Robo Expression
,
Multiple Functions for Slit/Robo in the Nervous SystemA Role for Slit and Robo in Neurological Disorders?; Perspectives; 6. NEUROTROPHIC FACTORS: ARE THEY AXON GUIDANCE MOLECULES?; Introduction; Evaluation of Neurotrophic Factors as Axon Guidance Molecules; The Discovery of the Neurotrophins; The Extended Family of Neurotrophic Factors; Neurotrophic Factors Can Promote Axon Growth and Orient Axons in Vitro; Neurotrophic Factors and Axon Guidance Molecules Use Common Signalling Pathways; The Role of Signalling Pathways in Axonal Chemoattraction by Neurotrophins and Netrin-l
,
Role of cAMP and Calcium Concentrations in ChemoattractionIn Vivo Tests of Neurotrophic Factors in Axon Guidance; Role of Neurotrophic Factors in Branching; Conclusions; 7. THE ROLE OF CELL ADHESION MOLECULES IN AXON GROWTH AND GUIDANCE; Introduction; Molecular Structure; Biophysical and Signaling Mechanisms; Functional Implication; Conclusion; 8. NEUROTRANSMITTERS AND THE DEVELOPMENT OF NEURONAL CIRCUITS; Introduction; Effects of Neurotransmitters on Growth Cone Steering; Glutamate: An Excitatory Transmitter and a Versatile Developmental Signal
,
Acetylcholine Acts as a Neuronal Guidance Signal during Brain DevelopmentThere Is More to GABA Than Synaptic Inhibition; Conclusions; 9. THE HEDGEHOG, TGF-ß/BMP AND Wnt FAMILIES OF MORPHOGENS IN AXON GUIDANCE; Introduction; Morphogens, Cell Fate Specification and Tissue Patterning; Morphogens in Axon Guidance; Interpreting Positional Information: Signaling Components in Axon Guidance and Cell Fate Specification; Conclusions and Perspectives; 10. THE ROLE OF CYCLIC NUCLEOTIDES IN AXON GUIDANCE; Introduction; Molecular Structure of Cyclic Nucleotides; Mechanisms of Signal Transduction
,
Functional Implications during Nervous System Development
Additional Edition:
ISBN 9780387767147
Additional Edition:
Buchausg. u.d.T. Axon growth and guidance New York, NY : Springer [u.a.], 2007 ISBN 9780387767147
Additional Edition:
ISBN 0387767142
Language:
English
Subjects:
Biology
Keywords:
Axon
;
Physiologie
;
Nervensystem
;
Wachstum
;
Axon
;
Wachstum
;
Genregulation
;
Aufsatzsammlung
DOI:
10.1007/978-0-387-76715-4
URL:
Volltext
(lizenzpflichtig)
