Umfang:
Online-Ressource (X, 255p, digital)
ISBN:
9783642168611
Serie:
Biology of Extracellular Matrix 2
Inhalt:
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
Anmerkung:
Includes bibliographical references and index
,
CONTENTS; 1 Matrix Metalloproteinases and Their Inhibitors in Turnoverand Degradation of Extracellular Matrix; 2 Role of Cysteine Cathepsins in Extracellular Proteolysis; 3 Cooperation Between Proteolysis and Endocytosisin Collagen Turnover; 4 Pericellular Proteolysis; 5 Triple Helicase Activity and the Structural Basisof Collagenolysis; 6 Structural Basis of Extracellular Matrix Interactionswith Matrix Metalloproteinases; 7 The Role of Matrix Metalloproteinases in CellularInvasion and Metastasis; 8 Degradation of Bone and the Role of Osteoclasts, BoneLining Cells and Osteocytes
,
9 Consequences of ElastolysisIndex
Weitere Ausg.:
ISBN 9783642168604
Weitere Ausg.:
Buchausg. u.d.T. Extracellular Matrix Degradation Berlin : Springer, 2011 ISBN 9783642168604
Weitere Ausg.:
ISBN 3642168604
Weitere Ausg.:
ISBN 9783642267802
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Extrazelluläre Matrix
;
Katabolismus
;
Proteasen
;
Extrazelluläre Matrix
;
Katabolismus
;
Proteasen
DOI:
10.1007/978-3-642-16861-1
URL:
Volltext
(lizenzpflichtig)
