Format:
Online-Ressource (XVI, 406 p. 40 illus., 31 illus. in color, digital)
ISBN:
9781461458470
,
1283911949
,
9781283911948
Series Statement:
Cell Death in Biology and Diseases 1
Content:
Defects in cell death pathways promote tumor development and progression, with potentially devastating consequences for cancer patients. Greater understanding of the defects occurring in cancer cells, and the unique characteristics of tumors which can make them vulnerable to cell death stimuli, offers tremendous opportunities for developing novel and effective anti-cancer therapies. In Cell Death in Cancer Biology and Treatment leading experts in the field provide a wealth of up-to-date knowledge regarding the molecular mechanisms and cell biological processes that control cell death. Each chapter also highlights recent advances in the translation of basic research findings into clinical trials. Beginning and established investigators alike will benefit from the thorough presentations of the most promising avenues for future development of cell death-based, anti-cancer strategies and agents. The volume begins with a detailed description of many of the cell death defects that have been identified in human tumor specimens. The unique bioenergetics of cancer cells, and the influence of the tumor microenvironment, autophagy, and cellular microRNAs on cancer cell death are then discussed, along with current progress in targeting these distinctive features and processes. Additional chapters describe recent advances, and the therapeutic benefits of targeting DNA repair pathways, protein chaperones, sphingolipid signaling, Bcl-2 family members, IAPs, death receptor signaling, the proteasome, and survival signaling emanating from the PI3K/AKT and RAS/RAF/MEK/ERK pathways. Finally, recent discoveries are presented regarding interactions between the immune system and dying cancer cells and the potential for optimizing these interactions to maximize anti-cancer activities. In summary, Cell Death in Cancer Biology and Treatment will be a valuable resource for scientists interested in cutting-edge understanding of aberrant cell death in cancer cells, and the multitude of innovative molecular targeting approaches that are actively being pursued to achieve selective activation of cell death in human malignancies.
Note:
Description based upon print version of record
,
Cell Death Signaling in Cancer Biology and Treatment; Series Preface; Contents; 1 Defective Apoptosis Signaling in CancerDaniel E. Johnson; 1.1 Characterization of a Human Disease and Biochemical Studies Unravel Apoptosis Signaling Pathways; 1.2 The Intrinsic and Extrinsic Apoptosis Pathways; 1.3 Defects in Caspase Signaling; 1.3.1 Mutation or Dysregulated Expression of Caspase Proteases; 1.3.2 Aberrant Expression of IAPs; 1.4 Defects Affecting the Intrinsic Apoptosis Pathway; 1.4.1 Overexpression of Anti-Apoptotic Bcl-2 Family Members
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1.4.2 Mutation or Reduced Expression of Proapoptotic Bcl-2 Family Members1.4.3 MutationDeletion of p53; 1.5 Defects Affecting the Extrinsic Apoptosis Pathway; 1.5.1 Loss or Mutation of Death Receptors; 1.5.2 Regulation of Death Receptor Signaling by Decoy Receptors, Aberrant Subcellular Trafficking, and p53; 1.5.3 FADD Mutation; 1.5.4 Dysregulated c-FLIP Expression; 1.6 Conclusions; References; 2 The Warburg Effect and Beyond: Metabolic Dependencies for Cancer CellsDavid M. Hockenbery, Mark Tom, Cori Abikoff and Daciana Margineantu; 2.1 Pre-Molecular Biology Research
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2.2 Glycolytic Regulation in Cancer2.3 Therapeutic Strategies Based on Glycolysis Inhibition; 2.4 Alternative Mitochondrial Fuels; 2.5 Screening for Additional Metabolic Dependencies; 2.6 Summary; References; 3 Emerging Opportunities for Targeting the Tumor-Stroma Interactions for Increasing the Efficacy of ChemotherapyRajesh R. Nair, Anthony W. Gebhard and Lori A. Hazlehurst; 3.1 Introduction; 3.2 Cellular Components of the Tumor Microenvironment Aiding Drug Resistance; 3.2.1 Mesenchymal Stroma Cells and Cancer-Associated Fibroblasts; 3.2.2 Immune Cells; 3.2.3 Endothelial Cells
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3.3 The Tumor Microenvironment Milieu and Drug Resistance and Tumor Progression3.3.1 Galectins; 3.3.2 Galectin-1; 3.3.3 Galectin-3; 3.3.4 Galectin-9; 3.4 Hypoxia and Drug Resistance; 3.5 Molecules Involved in the Interaction of the Tumor Cell with the Microenvironment; 3.5.1 Integrins; 3.5.2 CD44; 3.6 Signaling Pathways Activated Due to the Interaction of the Tumor Cell with the Microenvironment; 3.6.1 FAKPyk2; 3.7 Conclusion; References; 4 The Role of Autophagy in Drug Resistance and Potential for Therapeutic TargetingReshma Rangwala and Ravi Amaravadi; 4.1 Introduction
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4.2 Defining Autophagy4.3 The Core Machinery Required for Autophagy; 4.3.1 The Five Steps in the Autophagic Process; 4.3.1.1 Step 1: Induction; 4.3.1.2 Step 2: Vesicle Nucleation; 4.3.1.3 Step 3: Vesicle Expansion; 4.3.1.4 Step 4: Cargo Recruitment; 4.3.1.5 Step 5: Fusion with Lysosome, Lysosomal Degradation, and Recycling; 4.3.2 Redundancy, Non-Specificity, and the Non-Canonical Autophagy Program; 4.3.3 Unanswered Questions for the Autophagic Process; 4.4 Measuring Autophagy in Cancer Cells; 4.5 Molecular Links Between Autophagy and Signaling and Other Stress Pathways; 4.5.1 PI3KAktmTOR
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4.5.2 MAPK Signaling
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Defective Apoptosis Signaling in Cancer -- The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells -- Emerging Opportunities for Targeting the Tumor-Stroma Interactions for Increasing the Efficacy of Chemotherapy -- The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting -- microRNAs in Cell Death and Cancer -- Targeting DNA Repair Pathways for Cancer Therapy -- Molecular Chaperones and How Addiction Matters in Cancer Therapy -- Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment -- Leading Small Molecule Inhibitors of Anti-apoptotic Bcl-2 Family Members -- SMAC IAP Addiction in Cancer -- Harnessing Death Receptor Signaling for Cancer Treatment -- Proteasome Inhibition as a Novel Strategy for Cancer Treatment -- New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways -- Activation of Immune-Mediated Tumor Cell Death by Chemotherapy.
Additional Edition:
ISBN 9781461458463
Additional Edition:
Buchausg. u.d.T. Cell death signaling in cancer biology and treatment New York [u.a.] : Humana Press, 2013 ISBN 9781461458463
Language:
English
Subjects:
Biology
,
Medicine
Keywords:
Krebs
;
Apoptosis
;
Aufsatzsammlung
DOI:
10.1007/978-1-4614-5847-0
URL:
Volltext
(lizenzpflichtig)
