Format:
Online-Ressource (VII, 132 p. 11 illus., 9 illus. in color, online resource)
ISBN:
9783642402524
Series Statement:
Current Topics in Microbiology and Immunology 373
Content:
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity
Note:
Includes index
,
Development and Function of Cortical Thymic Epithelial CellsMechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
Additional Edition:
ISBN 9783642402517
Additional Edition:
Erscheint auch als Druck-Ausgabe Thymic development and selection of T Lymphocytes Berlin : Springer, 2014 ISBN 9783642402517
Additional Edition:
ISBN 3642402518
Language:
English
Keywords:
T-Lymphozyt
;
Zelldifferenzierung
DOI:
10.1007/978-3-642-40252-4
URL:
Volltext
(lizenzpflichtig)
