Bulletin of Shubun University, 2016, Issue 8, pp.1-9
[Abstract] Objectives : Serum levels of thyroid-stimulating hormone (TSH) and thyroglobulin (TG) were investigated in relation to thyroid malignancy to confirm the significance of both markers for cancer diagnosis, and also to decrease the false-negative rate in thyroid fine-needle aspiration (FNA) cytology. Methods : Preoperative serum levels of TSH and TG from 597 thyroid patients were statistically investigated. All patients had fine-needle aspiration cytology, then underwent surgical treatments, and their histological diagnoses were confirmed. The statistical significance of the TSH and TG levels was investigated. Results : TSH was significantly higher in cancer patients (P1.80 μIU/ml (P180 ng/ml (P1.80 μIU/ml have a higher risk of papillary carcinoma, and patients with TG〉180 ng/ml have a higher risk of follicular carcinoma. Even in patients with benign or inadequate results from FNA examinations, those with TSH〉1.80 μIU/ml have a higher risk of malignancy. Such patients should be further examined by repeat cytology or treated surgically to determine whether the lesion is malignant or not.
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