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  • 1
    Language: English
    In: Medical Microbiology and Immunology, 2009, Vol.198(4), pp.211-219
    Description: Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.
    Keywords: Neutrophils ; Innate immunity ; Pathophysiology ; Neutrophil extracellular traps
    ISSN: 0300-8584
    E-ISSN: 1432-1831
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