Umfang:
XXIV, 549 S.
,
Ill.
Ausgabe:
Online-Ausg. [S.l.] MyiLibrary Online-Ressource MyiLibrary
ISBN:
9783527333059
,
3527333053
Inhalt:
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics. Claudio Gualerzi is a full professor of Molecular Biology at the University of Camerino (Italy). For almost 20 years, he was also a research group leader at the Max-Planck-Institute for Molecular Genetics in Berlin (Germany). For his work on ribosome function and the discovery of novel antibiotics, Professor Gualerzi has received numerous awards and honorary lectureships, including the research prize of the Alexander von Humboldt foundation. Attilio Fabbretti is a research associate in the laboratory of Molecular Biology at the University of Camerino (Italy). He received the prize of the Italian Society for General Microbiology and Microbial Biotechnology for the best PhD thesis in 2007. Letizia Brandi is a research associate in the laboratory of Molecular Biology at the University of Camerino (Italy). Previously, she worked at the University of Montana (Missoula, USA) and at Vicuron Pharmaceuticals (Gerenzano, Italy). Cynthia Pon is full professor of Molecular and Microbial Genetics at the University of Camerino (Italy). She has been working on the structural and functional properties of ribosomes, including the action of ribosomal antibiotics, for more than 40 years.
Anmerkung:
Description based upon print version of record
,
Title Page; Copyright; Contents; Preface; List of Contributors; Chapter 1 A Chemist's Survey of Different Antibiotic Classes; 1.1 Introduction; 1.2 Aminoglycosides; 1.3 β-Lactams; 1.4 Linear Peptides; 1.4.1 Glycopeptides-Dalbaheptides; 1.4.2 Lantibiotics; 1.5 Cyclic Peptides; 1.6 Thiazolylpeptides; 1.7 Macrolactones; 1.7.1 Macrolides; 1.7.2 Difimicin; 1.8 Ansamycins-Rifamycins; 1.9 Tetracyclines; 1.10 Oxazolidinones; 1.11 Lincosamides; 1.12 Pleuromutilins; 1.13 Quinolones; 1.14 Aminocoumarins; References; Chapter 2 Antibacterial Discovery: Problems and Possibilities; 2.1 Introduction
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2.2 Why Is Antibacterial Discovery Difficult? The Problems2.3 Target Choice: Essentiality; 2.4 Target Choice: Resistance; 2.5 Cell Entry; 2.6 Screening Strategies; 2.6.1 Empirical Screens; 2.6.2 Phenotypic Whole-Cell Screens; 2.6.3 In Vitro Screens for Single-Target Inhibitors; 2.6.4 Chemicals to Screen; 2.6.4.1 Chemical Collections; 2.7 Natural Products; 2.8 Computational Chemistry, Virtual Screening, Structure- and Fragment-Based Drug Design (SBDD and FBDD); 2.9 Conclusions; References; Chapter 3 Impact of Microbial Natural Products on Antibacterial Drug Discovery; 3.1 Introduction
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3.2 Natural Products for Drug Discovery3.3 Microbial Natural Products; 3.4 The Challenge of Finding Novel Antibiotics from New Natural Sources; 3.5 Workflow for Drug Discovery from Microbial Natural Products; 3.6 Antimicrobial Activities: Targets for Screens; 3.7 Natural Products: A Continuing Source for Inspiration; 3.8 Genome Mining in Natural Product Discovery; 3.9 Conclusions; References; Chapter 4 Antibiotics and Resistance: A Fatal Attraction; 4.1 To Be or Not to Be Resistant: Why and How Antibiotic Resistance Mechanisms Develop and Spread among Bacteria
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4.1.1 Horizontal and Vertical Transmission of Resistance Genes4.2 Bacterial Resistance to Antibiotics by Enzymatic Degradation or Modification; 4.2.1 Antibiotic Resistance by Hydrolytic Enzymes; 4.2.1.1 β-Lactamases; 4.2.1.2 Macrolide Esterases; 4.2.1.3 Epoxidases; 4.2.1.4 Proteases; 4.2.2 Antibiotic Transferases Prevent Target Recognition; 4.2.2.1 Acyltransfer; 4.2.2.2 Phosphotransferases; 4.2.2.3 Nucleotidyltransferases; 4.2.2.4 ADP-Ribosyltransferases; 4.2.2.5 Glycosyltransferases; 4.2.3 Redox Enzymes; 4.3 Antibiotic Target Alteration: The Trick Exists and It Is in the Genetics
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4.3.1 Low-Affinity Homologous Genes4.3.1.1 Rifamycin Low-Affinity RpoB; 4.3.1.2 Mutated Genes Conferring Resistance to Quinolone, Fluoroquinolone and Aminocoumarins; 4.3.1.3 PBP2a: A Low-Affinity Penicillin-Binding Protein; 4.3.1.4 Dihydropteroate Synthases Not Inhibited by Sulfonamide; 4.3.2 Chemical Modification of Antibiotic Target; 4.3.2.1 23S rRNA Modification; 4.3.2.2 16S rRNA Modification; 4.3.2.3 Reprogramming Chemical Composition of a Bacterial Cell-Wall Precursor; 4.3.3 Ribosomal Protection and Tetracycline Resistance
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4.3.4 Chromosomal Mutations in Genes Required for Membrane Phospholipid Metabolism: Lipopeptide Resistance
Weitere Ausg.:
9783527659715
Weitere Ausg.:
9783527333059
Weitere Ausg.:
Druckausg. Antibiotics Weinheim : Wiley-VCH-Verl., 2014 9783527333059
Weitere Ausg.:
3527333053
Sprache:
Englisch
Fachgebiete:
Chemie/Pharmazie
,
Medizin
Schlagwort(e):
Antibiotikum
;
Electronic books
;
Aufsatzsammlung
URL:
Volltext
(lizenzpflichtig)
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