Kooperativer Bibliotheksverbund

UID:

Format: Online-Ressource (XI, 569 p. 80 illus., 48 illus. in color, digital)

ISBN: 9781461459309

Series Statement: Advances in Biochemistry in Health and Disease 5

Additional Edition: ISBN 9781461459293

Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-45929-3

Language: English

DOI: 10.1007/978-1-4614-5930-9

URL: Volltext

URL: Cover

UID:

Format: Online-Ressource (XVIII, 532 p. 66 illus., 52 illus. in color, digital)

ISBN: 9781461458579

Series Statement: Advances in Biochemistry in Health and Disease 6

Content: Angiogenesis plays a key role in human physiology and pathophysiology. While necessary for tissue growth and development, uncontrolled angiogenesis plays a role in the progression of certain tumors as well as atherosclerosis. Lack of angiogenesis may be the basis of myocardial ischemia and stroke. Knowledge on the mechanisms of angiogenesis is growing very rapidly, and may lead to important drugs for therapy of a variety of clinical disorders. Experts from around the world have contributed a vast array of data on different aspects of angiogenesis in this volume edited by Professors Mehta and Dhalla. This information will be of immense help to basic scientists, clinicians and those involved in drug development

Note: Description based upon print version of record , Biochemical Basis and Therapeutic Implications of Angiogenesis; Preface; Contents; Contributors; Part I:Molecular Mechanisms of Angiogenesis; Chapter 1: Endothelial Growth Factor Receptors in Angiogenesis; 1.1 Introduction: The Signaling Axes Behind Angiogenesis; 1.2 The VEGF Axis; 1.2.1 VEGF Structure and Function; 1.2.1.1 The VEGF Receptors; VEGFR-1; VEGFR-2; VEGFR-3; 1.3 Co-receptors; 1.4 The Role of the Endothelial Growth Factor Receptors in Angiogenesis and Neovascularization; 1.4.1 The Role of the Endothelial Growth Factor Receptors in Tumorigenesis; 1.4.1.1 VEGFR-1; 1.4.1.2 VEGFR-2 , 1.4.1.3 VEGFR-31.4.1.4 Prognosis; 1.4.1.5 Metastasis; 1.4.1.6 Autocrine Signaling; 1.4.1.7 Therapeutic Applications; 1.4.2 The Eye; 1.4.2.1 Therapeutic Applications; 1.4.3 Pro-angiogenic Therapies; 1.5 Conclusion; References; Chapter 2: Role of Transforming Growth Factor Beta in Angiogenesis; 2.1 TGFb Molecule Family: Sources, Activation, and Regulation of Transcription; 2.1.1 The TGFb Family; 2.1.2 TGFb Sources; 2.1.3 Synthesis and Activation of TGFb; 2.1.4 Regulation of Transcription by TGFb; 2.1.5 TGFb's Role in Angiogenesis; 2.2 TGFb Receptors and Signaling; 2.2.1 Canonical Smad Signaling , 2.2.2 Noncanonical Signaling Pathways2.2.2.1 MAPK; 2.2.2.2 Rho-GTPase; 2.2.2.3 PI3K (AKT); 2.3 TGFb and Endothelial Sprouting, Proliferation, and Permeability; 2.3.1 Endothelial Sprouting; 2.3.2 Endothelial Permeability; 2.3.3 Endothelial Proliferation and Migration; 2.4 TGFb Co-receptors in Angiogenesis; 2.4.1 Regulation of TGFb Ligand Access to Co-receptors; 2.5 TGFb and Vascular Mural Cells; 2.6 Pathological Angiogenesis; 2.6.1 HHT; 2.6.2 Organ Fibrosis; 2.6.3 Cancer; 2.7 Conclusion; References; Chapter 3: Role of Cytokines in Angiogenesis: Turning It On and Off; 3.1 Introduction , 3.2 The Sequential Steps of Angiogenesis: Vessel Branching, Maturation, and Quiescence3.3 The Players; 3.4 VEGF; 3.5 Notch; 3.6 FGF; 3.7 Ephrin and Ephrin Receptors; 3.8 TGF-b; 3.9 Platelet-Derived Growth Factor; 3.10 Angiopoietins and Tie Receptors; 3.11 Chemokines and G Protein-Coupled Receptors; 3.12 Inhibitors of Angiogenesis; 3.13 Cytokines in Tumor Angiogenesis; 3.14 Conclusion; References; Chapter 4: Neuropeptides and Angiogenesis; 4.1 Introduction; 4.2 Neuropeptide Y; 4.3 NPY and Angiogenesis; 4.4 Substance P; 4.5 SP and Angiogenesis; 4.6 Calcitonin Gene-Related Peptide , 4.7 CGRP and Angiogenesis4.8 Vasoactive Intestinal Peptide; 4.9 VIP and Angiogenesis; 4.10 Somatostatin; 4.11 Somatostatin and Angiogenesis; 4.12 Conclusions; References; Chapter 5: Role of Integrins in Angiogenesis; 5.1 Introduction; 5.2 Bidirectional Signaling by Integrins Regulates Cellular Fate; 5.3 Integrin Binding to Proteolytic Protein Fragments; 5.4 Cross talk of Integrins with Other Signaling Pathways; 5.4.1 Notch Signaling; 5.4.2 VEGF Signaling; 5.4.3 TGF-b Signaling; 5.5 Integrin Inhibition in Tumor Angiogenesis; 5.6 Integrin Inhibitors in Clinical Development; 5.6.1 Cilengitide , 5.6.2 ATN-161 , Part A: Molecular Mechanisms of Angiogenesis -- Endothelial Growth Factor Receptors in Angiogenesis -- Role of Transforming Growth Factor Beta in Angiogenesis -- Role of Cytokines in Angiogenesis: Turning it On and Off -- Neuropeptides in Angiogenesis -- The Role of Integrins in Angiogenesis -- Regulation of Angiogenesis by Hypoxia-inducible Factors -- Role of Mast Cells in Angiogenesis -- Vascular Stem Cells in Regulation of Angiogenesis -- Toll-like Receptor-linked Signal Transduction in Angiogenesis -- The Role of Sex Steroids in Angiogenesis -- Biochemical Mechanisms of Exercise-induced Angiogenesis -- Part B: Pathophysiological Aspects of Angiogenesis -- Angiogenesis in Atherosclerosis: An Overview -- Role of Serotonin in Angiogenesis in Diabetes -- Brain Angiogenesis after Stroke -- Angiogenesis in Myocardial Ischemia -- Adipose Tissue-derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease -- Trials of Angiogenesis Therapy in Patients with ischemic Heart Disease -- Angiogenesis in Cancer -- Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer -- Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small Cell Lung Cancer Tumor Behavior -- Part C: Pharmacology and Therapy of Angiogenesis -- Angiogenesis and Arteriogenesis Factors: Their Role in the Treatment of Cancer and Arterial Regeneration -- Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis -- Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis -- Microarray and MiRs in Angiogenesis -- MicroRNA and Cardiovascular Disorders, with a Focus on Angiogenesis -- An Overview of Angiogenesis Inhibitors from Natural Sources -- Index.

Additional Edition: ISBN 9781461458562

Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-45856-2

Language: English

DOI: 10.1007/978-1-4614-5857-9

URL: Volltext

URL: Volltext  (lizenzpflichtig)

UID:

Format: Online-Ressource (XI, 462 p. 58 illus., 46 illus. in color, online resource)

ISBN: 9781461490999

Series Statement: Advances in Biochemistry in Health and Disease 8

Content: It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteosomal system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects

Note: Description based upon print version of record , Part A: Proteases and Neural Disorders.- Role of Calpain in Immunobiology of Neurodegenerative Diseases.- Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration.- Involvement of Caspases in Neurodegenaration and Stroke.- Matrix Metalloproteinases in Ischemia-Reperfusion Injury in Brain: Antioxidants as Rescuer.- The Role of Matrix Metalloproteinases in Neurovascular Injury.- The Role of Proteases in Embryonic Neural Crest Cells.- Part B: Proteases and Cancer     Proteases and Cancer Development.- Matrix Metalloproteinase and its Inhibitors in Cancer Progression.- Ubiquitin-Proteosome System in the Hallmarks of Cancer.- Matrix Metalloproteinases in Cancer Metastasis: An unsolved Mystery.- A Disintegrin and Metalloprotease-12 as a New target for Cancer Treatment -- Proteases and Their Role in Drug Development with an Emphasis in Cancer.- Part C: Proteases and Cardiovascular Defects.- Role of Matrix Metalloproteinases in Atherosclerosis.- The Importance of the Urokinase-type Plasminogen Activator (uPA) and its receptor (uPAR) for the Development and Progression of Atherosclerosis.- Matrix Metalloproteinases and Hypertension.- Regulation of Proteolysis in Vascular Remodeling.- Emerging Role of Genetic Variants of Matrix Metalloproteinases Genes in Left Ventricular Dysfunction.- Implications of Intracellular Proteolytic Activation of MMP-2 in the Heart.- Matrix Metalloprotease-2 in the Development and Progression of Cardiovascular Diseases.- Role of Protease Activation in Subcellular Remodeling and Heart Failure.- Proteases as Potential Targets in Left Ventricular Remodeling After Myocardial Infarction.- MMPs in Cardiovascular Diseases: Emerging Pharmacological Targets.- Proteases as Clinical Markers of Adverse Remodeling for Heart Failure in the Aging Population.

Additional Edition: ISBN 9781461490982

Additional Edition: Druckausg. ISBN 978-146-149-098-2

Language: English

DOI: 10.1007/978-1-4614-9099-9

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (XIX, 410 p. 69 illus., 53 illus. in color, online resource)

ISBN: 9781493904648

Series Statement: Advances in Biochemistry in Health and Disease 10

Content: Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development

Note: Description based upon print version of record , Phospholipases in Health and DiseaseRole of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodelling in the Heart and Mammalian Cells -- Role of Phospholipases and Oxidized Phospholipids in Inflammation -- Phospholipases in Cardiovascular Disease -- The Structures and Functions of Intracellular Phospholipase A1 Family Proteins -- Phospholipase A and Breast Cancer -- Pathophysiological Aspects of Lipoprotein Associated Phospholipase A2: A Brief Overview -- Phospholipase A2 Activity Exhibited by a Bacterial Virulence Protein that Enters and Operates within a Variety of Host Cells -- Expression and Role of Phospholipase A2 in Central Nervous System Injury and Disease -- Cytoplasmic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers -- Phospholipase A2 Enzymes: Potential Targets for Therapy -- The Role of Phospholipase C Isozymes in Cellular Homeostasis -- Phospholipase C in the Immune Cell -- Phosphoinositide-specific Phospholipase C Enzymes and Cognitive Development  and Decline -- Where life begins: Sperm PLCz in mammalian egg activation and implications in male infertility -- Oocyte Activation and Phospholipase C zeta (PLCζ): Male Infertility and  Implications for Therapeutic Intervention -- Phospholipase C Signaling in Heart Disease -- Activation of Phospholipase C in Cardiac Hypertrophy -- The Protective Effect of Phospholipase C From Cardiac Ischemia-Reperfusion Injury -- Role of Phospholipase C in Cardioprotection During Oxidative Stress -- Mammalian Phospholipase D: Structure, Regulation and Physiological Functions of Phospholipase D and its Link to Pathology -- Emerging Roles of Phospholipase D in Pathophysiological Signaling -- Alterations in Phospholipase D During the Development of Myocardial Disease.

Additional Edition: ISBN 9781493904631

Additional Edition: Druckausg. ISBN 978-149-390-463-1

Language: English

Subjects: Biology , Medicine

Keywords: Phospholipasen

DOI: 10.1007/978-1-4939-0464-8

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (XV, 295 p. 54 illus., 25 illus. in color, online resource)

ISBN: 9781493912278

Series Statement: Advances in Biochemistry in Health and Disease 11

Content: The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional, and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction, and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals

Note: Description based upon print version of record , Part 1. Control of Energy Metabolism1. A Primer on Carbohydrate Metabolism in the Heart -- 2. Lipoproteins: A Source of Cardiac Lipids -- 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart -- 4. Control of Myocardial Fatty Acid Uptake -- 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes -- 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation -- 7. Relationship between Substrate Metabolism and Cardiac Efficiency -- 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity -- Part 2. Alteration in Energy Metabolism -- 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes -- 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart -- 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure -- 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury -- 13. The Role of AMPK in the Control of Cardiac Hypertrophy -- 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance -- Part 3. Optimization of Energy Metabolism -- 15. Metabolic Therapy for the Ischemic Heart -- 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients -- 17. Cardiac Metabolic Protection for the Newborn Heart -- 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease.

Additional Edition: ISBN 9781493912261

Additional Edition: Druckausg. ISBN 978-149-391-226-1

Language: English

DOI: 10.1007/978-1-4939-1227-8

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

ISBN: 9783802592041

Series Statement: Psy Changeling

Content: "Vergessen Sie alles, was Sie bislang zu wissen glaubten! Über Geheimnisse. Über Rache. Über Verlust und Schmerz. Der Tag der Abrechnung ist gekommen! Ein Roman, der die Welt der Gestaltwandler erschüttern wird - mit der schockierenden Antwort auf eine explosive Frage, die schon jetzt die Leserinnen in aller Welt in Atem hält. Die sensationelle Fortsetzung von Nalini Singhs Gestaltwandlerserie ist ein Muss für jeden Fan!"

Language: German

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Author information: Singh, Nalini

UID:

Format: 363 Seiten

ISBN: 9783955763350 , 9783955763350

Content: Sinnliche Stunden mit dir: Nie hat Andrea ihren Exchef vergessen! Plötzlich tritt Jackson Santorini wieder in ihr Leben - und will sie heiraten. Allerdings nur, damit sie weiterhin für ihren Halbbruder sorgen kann. Dabei sehnt sie sich nach sinnlichen Stunden in Jacksons Armen... Nächte der Liebe - Tage der Hoffnung: Eine Ehe wie ein Geschäftsvertrag! Jessica soll ihm einen Erben schenken, im Gegenzug rettet Gabriel Dumont ihr Anwesen. Tagsüber ist er kühl. Doch nachts entführt er sie in den Himmel der Leidenschaft. Jessica wünschte, diese Nächte würden nie enden... Die schöne Hira und ihr Verführer: Hochzeitsnacht hin oder her! Hira denkt nicht daran, dieses Bett voll Samt und Seide mit ihrem Mann zu teilen. Erstens hat ihr Vater die Ehe mit dem - zugegeben sexy - Unternehmer arrangiert. Zweitens liebt Marc sie nicht. Oder was bedeuten seine feurigen Blicke?

Language: German

URL: http://voebb.onleihe.de/berlin/frontend/mediaInfo,0-0-390315578-100-0-0-0-0-0-0-0.html

Author information: Singh, Nalini

UID:

ISBN: 9781625175397

Series Statement: Rock Kiss

Content: " New York Times bestselling author Nalini Singh's new contemporary romance novella is pure hard rock and scorching heat... What happens when the Gentleman of Rock decides to play dirty? A drummer for the hottest rock band on the planet, David has a single, powerful weakness: Thea, the band's publicist and the woman who steals his breath away with her every move. Only problem is, Thea doesn't date clients—or musicians. Emotionally scarred by a cheating ex, she's not about to risk her heart with a man who has groupies buzzing around him like flies. Even if his sexy smile ties her up in knots. What she doesn't know is that David is a one-woman man...and he's madly in love with her. David's determined to prove he's worth the risk, and willing to court her, step by exquisite step. Thea's about to discover just how long and hard this handsome drummer can play."

Content: Rezension(1): " Nalini Singh loves to write, loves to read, and thinks chocolate is a food group. She enjoys hearing from readers, so drop her an email at nalinisinghwritesATgmailDOTcom if you ever have any questions! Website: nalinisingh.com"

Language: English

URL: https://samples.overdrive.com/rock-courtship?.epub-sample.overdrive.com

URL: http://voebb.lib.overdrive.com/ContentDetails.htm?ID=BAE24A94-0F8A-43C4-88BE-A714F17267CB

Author information: Singh, Nalini

UID:

ISBN: 9781937776985

Series Statement: Rock Kiss

Content: " New York Times bestselling author Nalini Singh stuns with a sizzling contemporary romance... A bad boy wrapped in a sexy, muscled, grown-up package might be worth a little risk... Molly Webster has always followed the rules. After an ugly scandal tore apart her childhood and made her the focus of the media's harsh spotlight, she vowed to live an ordinary life. No fame. No impropriety. No pain. Then she meets Zachary Fox, a tattooed bad boy rocker with a voice like whiskey and sin, and a touch that could become an addiction. A one-night stand with the hottest rock star on the planet, that's all it was meant to be... Fox promises scorching heat and dangerous pleasure, coaxing Molly to extend their one-night stand into a one-month fling. After that, he'll be gone forever, his life never again intersecting with her own. Sex and sin and sensual indulgence, all with an expiration date. No ties, no regrets. Too late, Molly realizes it isn't only her body that's become addicted to Fox, but her heart..."

Content: Rezension(1): "New York Times and USA Today bestselling author of the Psy-Changeling and Guild Hunter series Nalini Singh usually writes about hot shapeshifters and dangerous angels. This time around, she decided to write about a hot and wickedly tempting rock star. If you're seeing a theme here, you're not wrong. Nalini lives and works in beautiful New Zealand, and is passionate about writing. If you'd like to explore her other books, you can find lots of excerpts on her website: www.nalinisingh.com. Slave to Sensation is the first book in the Psy-Changeling series, while Angels' Blood is the first book in the Guild Hunter series. The site also has a special section dedicated to the Rock Kiss series, complete with photos of many of the locations used in the books."

Language: English

URL: https://samples.overdrive.com/rock-addiction?.epub-sample.overdrive.com

URL: http://voebb.lib.overdrive.com/ContentDetails.htm?ID=833E14B4-EA28-4715-8DB0-0650E7237382

Author information: Singh, Nalini

UID:

ISBN: 9783802590610

Series Statement: Anthologien

Content: "Packende Geschichten zu Nalini Singhs Gestaltwandlerserie und ihren erfolgreichen Engelromanen. In einer Welt voller Schönheit und Blutgier, in der Engel über Vampire und Sterbliche herrschen, in der Mediale versuchen, die Emotionen zu verbieten und Gestaltwandler um das Überleben kämpfen, brodeln die Gefühle - Rache, Hass und Leidenschaft. Jeder ist auf der Suche nach einer Liebe, die alle Grenzen überwindet ..."

Language: German

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Author information: Singh, Nalini

Author information: Röser, Cornelia