Umfang:
Online-Ressource (XVIII, 532 p. 66 illus., 52 illus. in color, digital)
ISBN:
9781461458579
Serie:
Advances in Biochemistry in Health and Disease 6
Inhalt:
Angiogenesis plays a key role in human physiology and pathophysiology. While necessary for tissue growth and development, uncontrolled angiogenesis plays a role in the progression of certain tumors as well as atherosclerosis. Lack of angiogenesis may be the basis of myocardial ischemia and stroke. Knowledge on the mechanisms of angiogenesis is growing very rapidly, and may lead to important drugs for therapy of a variety of clinical disorders. Experts from around the world have contributed a vast array of data on different aspects of angiogenesis in this volume edited by Professors Mehta and Dhalla. This information will be of immense help to basic scientists, clinicians and those involved in drug development
Anmerkung:
Description based upon print version of record
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Biochemical Basis and Therapeutic Implications of Angiogenesis; Preface; Contents; Contributors; Part I:Molecular Mechanisms of Angiogenesis; Chapter 1: Endothelial Growth Factor Receptors in Angiogenesis; 1.1 Introduction: The Signaling Axes Behind Angiogenesis; 1.2 The VEGF Axis; 1.2.1 VEGF Structure and Function; 1.2.1.1 The VEGF Receptors; VEGFR-1; VEGFR-2; VEGFR-3; 1.3 Co-receptors; 1.4 The Role of the Endothelial Growth Factor Receptors in Angiogenesis and Neovascularization; 1.4.1 The Role of the Endothelial Growth Factor Receptors in Tumorigenesis; 1.4.1.1 VEGFR-1; 1.4.1.2 VEGFR-2
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1.4.1.3 VEGFR-31.4.1.4 Prognosis; 1.4.1.5 Metastasis; 1.4.1.6 Autocrine Signaling; 1.4.1.7 Therapeutic Applications; 1.4.2 The Eye; 1.4.2.1 Therapeutic Applications; 1.4.3 Pro-angiogenic Therapies; 1.5 Conclusion; References; Chapter 2: Role of Transforming Growth Factor Beta in Angiogenesis; 2.1 TGFb Molecule Family: Sources, Activation, and Regulation of Transcription; 2.1.1 The TGFb Family; 2.1.2 TGFb Sources; 2.1.3 Synthesis and Activation of TGFb; 2.1.4 Regulation of Transcription by TGFb; 2.1.5 TGFb's Role in Angiogenesis; 2.2 TGFb Receptors and Signaling; 2.2.1 Canonical Smad Signaling
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2.2.2 Noncanonical Signaling Pathways2.2.2.1 MAPK; 2.2.2.2 Rho-GTPase; 2.2.2.3 PI3K (AKT); 2.3 TGFb and Endothelial Sprouting, Proliferation, and Permeability; 2.3.1 Endothelial Sprouting; 2.3.2 Endothelial Permeability; 2.3.3 Endothelial Proliferation and Migration; 2.4 TGFb Co-receptors in Angiogenesis; 2.4.1 Regulation of TGFb Ligand Access to Co-receptors; 2.5 TGFb and Vascular Mural Cells; 2.6 Pathological Angiogenesis; 2.6.1 HHT; 2.6.2 Organ Fibrosis; 2.6.3 Cancer; 2.7 Conclusion; References; Chapter 3: Role of Cytokines in Angiogenesis: Turning It On and Off; 3.1 Introduction
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3.2 The Sequential Steps of Angiogenesis: Vessel Branching, Maturation, and Quiescence3.3 The Players; 3.4 VEGF; 3.5 Notch; 3.6 FGF; 3.7 Ephrin and Ephrin Receptors; 3.8 TGF-b; 3.9 Platelet-Derived Growth Factor; 3.10 Angiopoietins and Tie Receptors; 3.11 Chemokines and G Protein-Coupled Receptors; 3.12 Inhibitors of Angiogenesis; 3.13 Cytokines in Tumor Angiogenesis; 3.14 Conclusion; References; Chapter 4: Neuropeptides and Angiogenesis; 4.1 Introduction; 4.2 Neuropeptide Y; 4.3 NPY and Angiogenesis; 4.4 Substance P; 4.5 SP and Angiogenesis; 4.6 Calcitonin Gene-Related Peptide
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4.7 CGRP and Angiogenesis4.8 Vasoactive Intestinal Peptide; 4.9 VIP and Angiogenesis; 4.10 Somatostatin; 4.11 Somatostatin and Angiogenesis; 4.12 Conclusions; References; Chapter 5: Role of Integrins in Angiogenesis; 5.1 Introduction; 5.2 Bidirectional Signaling by Integrins Regulates Cellular Fate; 5.3 Integrin Binding to Proteolytic Protein Fragments; 5.4 Cross talk of Integrins with Other Signaling Pathways; 5.4.1 Notch Signaling; 5.4.2 VEGF Signaling; 5.4.3 TGF-b Signaling; 5.5 Integrin Inhibition in Tumor Angiogenesis; 5.6 Integrin Inhibitors in Clinical Development; 5.6.1 Cilengitide
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5.6.2 ATN-161
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Part A: Molecular Mechanisms of Angiogenesis -- Endothelial Growth Factor Receptors in Angiogenesis -- Role of Transforming Growth Factor Beta in Angiogenesis -- Role of Cytokines in Angiogenesis: Turning it On and Off -- Neuropeptides in Angiogenesis -- The Role of Integrins in Angiogenesis -- Regulation of Angiogenesis by Hypoxia-inducible Factors -- Role of Mast Cells in Angiogenesis -- Vascular Stem Cells in Regulation of Angiogenesis -- Toll-like Receptor-linked Signal Transduction in Angiogenesis -- The Role of Sex Steroids in Angiogenesis -- Biochemical Mechanisms of Exercise-induced Angiogenesis -- Part B: Pathophysiological Aspects of Angiogenesis -- Angiogenesis in Atherosclerosis: An Overview -- Role of Serotonin in Angiogenesis in Diabetes -- Brain Angiogenesis after Stroke -- Angiogenesis in Myocardial Ischemia -- Adipose Tissue-derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease -- Trials of Angiogenesis Therapy in Patients with ischemic Heart Disease -- Angiogenesis in Cancer -- Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer -- Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small Cell Lung Cancer Tumor Behavior -- Part C: Pharmacology and Therapy of Angiogenesis -- Angiogenesis and Arteriogenesis Factors: Their Role in the Treatment of Cancer and Arterial Regeneration -- Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis -- Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis -- Microarray and MiRs in Angiogenesis -- MicroRNA and Cardiovascular Disorders, with a Focus on Angiogenesis -- An Overview of Angiogenesis Inhibitors from Natural Sources -- Index.
Weitere Ausg.:
ISBN 9781461458562
Weitere Ausg.:
Buchausg. u.d.T. ISBN 978-1-461-45856-2
Sprache:
Englisch
DOI:
10.1007/978-1-4614-5857-9
URL:
Volltext
(lizenzpflichtig)
