In:
Alimentary Pharmacology & Therapeutics, Wiley, Vol. 41, No. 10 ( 2015-05), p. 980-990
Abstract:
The relationships between primary sclerosing cholangitis ( PSC ) and the environment are largely unknown. Aim To validate associations reported in previous studies and to identify novel environmental exposures among PSC patients. Methods We performed a multicenter, case–control analysis utilising self‐administered questionnaires. Responses between cases ( n = 1000) and controls ( n = 663) were compared using multivariable logistic regression adjusted for age and gender. The model was further stratified based on inflammatory bowel disease ( IBD ) status (with IBD n = 741 without IBD n = 259). Results Smoking was associated with PSC only when IBD was present ( OR , 0.5; 95% CI 0.4–0.7) but not among those PSC patients without IBD ( OR , 0.9; 95% CI 0.7–1.2). Compared to controls, women with PSC (irrespective of the presence of IBD ) were less likely to have received hormone replacement therapy ( HRT ; OR , 0.5; 95% CI 0.4–0.7) and were more likely to have recurrent urinary tract infections ( OR , 1.6; 95% CI 1.2–2.3). PSC patients regardless of gender or IBD status were less likely to eat fish ( OR , 0.4; 95% CI 0.3–0.6) and grilled/barbecued meat ( OR , 0.8; 95% CI 0.7–0.9). In contrast, PSC patients with and without IBD were more likely to consume steak/burgers that were more well done ( OR , 1.3; 95% CI 1.2–1.5). Conclusions IBD (rather than PSC ) is associated with smoking. Women with PSC are more likely to have recurrent urinary tract infections and less likely to receive HRT . Dietary intake and methods of food preparation differ in PSC patients when compared to controls.
Type of Medium:
Online Resource
ISSN:
0269-2813
,
1365-2036
DOI:
10.1111/apt.2015.41.issue-10
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2003094-0
SSG:
15,3
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