In:
British Journal of Clinical Pharmacology, Wiley, Vol. 89, No. 3 ( 2023-03), p. 1012-1019
Kurzfassung:
Anaphylaxis guidelines recommend intramuscular adrenaline, commonly 300 μg administered using an auto‐injector device. However, overweight/obese patients may require a higher adrenaline dose for adequate cardiovascular (CV) response. This study evaluated the pharmacokinetics (PK) and pharmacodynamic (PD) CV profiles after a single 500 μg adrenaline injection via Anapen auto‐injector in healthy normal weight males and otherwise healthy, overweight or obese females. Methods In this exploratory open‐label, single‐centre study, 54 healthy volunteers aged 18‐50 years received a single 500 μg adrenaline injection (Anapen auto‐injector) in the thigh (antero‐lateral middle third [18 males] or antero‐inferior third [36 females] ). Assessments included depot depth (ultrasonography), plasma adrenaline levels (liquid chromatography‐tandem mass spectrometry) and heart rate (HR; ECG Holter monitor). Results Ultrasonography showed that 82.4% of normal weight males received intramuscular injections; all overweight and obese females received subcutaneous injections. Anapen injection produced rapid increases in circulating adrenaline levels and significant increases in systolic blood pressure (SBP) and HR. Second peak plasma adrenaline concentrations ( C max2 ) were reduced, and time to C max2 increased in overweight and obese females compared with males with normal body mass index; area under the curve (0–240 min) (AUC (0‐240) ) was increased in overweight and obese females. Obese females had reduced maximal SBP values compared with normal weight males or overweight females; overweight and obese females had markedly different HR time courses compared with normal weight males. Conclusion A 500 μg adrenaline injection via Anapen produced rapid PK/PD changes in normal weight, overweight and obese subjects, irrespective of intramuscular or subcutaneous injection, and was well tolerated.
Materialart:
Online-Ressource
ISSN:
0306-5251
,
1365-2125
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2023
ZDB Id:
1498142-7
SSG:
15,3
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