Format:
Online-Ressource
ISSN:
1615-9314
Content:
Abstract: (S)‐N‐(3,5‐dinitrobenzoyl) leucine‐N‐phenyl‐N‐propylamine‐bonded silica was used as a chiral stationary phase for separation of a set of racemic π‐acidic and π‐basic α‐amino acid amides in electrolyteless ACN‐water eluents by CEC in the RP and polar organic (PO) modes. The effect of the amount of water in the ACN‐water eluent on chiral separation was examined. As water is added to ACN, retention was shortened but resolution and selectivity deteriorated severely. Retention, enantioselectivity, and resolution factors obtained in 100% ACN were compared with those in an n‐hexane‐isopropanol eluent with a small amount of water by normal phase (NP) CEC. Much shorter retention times with comparable enantioselectivities were observed with 100% ACN, demonstrating the advantage of separation on (S)‐N‐(DNB) leucine‐N‐phenyl‐N‐propylamine‐bonded silica in PO‐CEC over NP‐CEC.
In:
volume:32
In:
number:14
In:
year:2009
In:
pages:2421-2425
In:
extent:5
In:
Journal of separation science, Weinheim : Wiley-VCH, [2000]-, 32, Heft 14 (2009), 2421-2425 (gesamt 5), 1615-9314
Language:
English
DOI:
10.1002/jssc.200900105
URN:
urn:nbn:de:101:1-2023041410113406411904
URL:
https://doi.org/10.1002/jssc.200900105
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023041410113406411904
URL:
https://d-nb.info/1286233879/34
URL:
https://doi.org/10.1002/jssc.200900105
Bookmarklink