Format:
1 Online-Ressource (PDF-Datei: 42 Seiten, 4184 Kilobyte)
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Illustrationen (teilweise farbig), Diagramme (farbig)
Content:
Pankreaskarzinom, miRNA, miR-502, cNHEJ
Content:
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Acquired inherited and/or somatic mutations drive its development. In order to prevent the formation of these mutations, precise and immediate repair of any DNA damage is indispensable. Non-homologous end-joining (NHEJ) is the key mechanism of DNA double-strand break repair. Here, we report that miR-502 targets two components in pancreatic cell lines, Ku70 and XLF of the C-NHEJ. Interestingly, we also observed an attenuated cell cycle response to gamma ionizing radiation (γ-IR) via diminished phosphorylation of checkpoint kinase 1 (Chk1) on serine 345 in these cell lines. Altogether, pancreatic cells showed increased susceptibility to γ-IR via direct inhibition of DNA double-strand break repair and attenuation of the cell cycle response.
Note:
Literaturverzeichnis: Seite 23-27
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Dissertation Universitätsmedizin der Universität Greifswald 2021
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Text deutsch, Publikation englisch
Additional Edition:
Erscheint auch als Druck-Ausgabe Swoboda, Julia, 1991 - Der Einfluss von miR-502 auf die klassische nichthomologe Rekombination im duktalen Adenokarzinom des Pankreas Greifswald, 2021
Language:
English
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German
Keywords:
Bauchspeicheldrüsenkrebs
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miRNS
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DNS-Reparatur
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Hochschulschrift
URN:
urn:nbn:de:gbv:9-opus-58205
URL:
https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-58205
URL:
https://d-nb.info/1249921554/34
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