Format:
Online-Ressource
ISSN:
1613-4133
Content:
Scope: Anti‐inflammatory effects of coffee consumption have been reported to be caused by caffeine and adenosine receptor signaling. However, contradictory effects have been observed. Many kinds of chronic diseases are linked to inflammation; therefore a profound understanding of potential effects of coffee consumption is desirable. Methods and results: We performed ex vivo experiments with eight individuals investigating peripheral blood mononuclear cells isolated from venous blood before and after coffee consumption, as well as in vitro experiments applying caffeine on isolated cells. After in vitro inflammatory stimulation of the cells, released cytokines, chemokines, and eicosanoids were determined and quantified using targeted mass spectrometric methods. Remarkably, the release of inflammation mediators IL6, IL8, GROA, CXCL2, CXCL5 as well as PGA2, PGD2, prostaglandin E2 (PGE2), LTC4, LTE4, and 15S‐HETE was significantly affected after coffee consumption. While in several individuals coffee consumption or caffeine treatment caused significant downregulation of most inflammation mediators, in other healthy individuals exactly the opposite effects were observed. Conclusion: Ruling out age, sex, coffee consumption habits, the metabolic kinetics of caffeine in blood and the individual amount of regulatory T cells or CD39 expression as predictive parameters, we demonstrated here that coffee consumption may have significant pro‐ or anti‐inflammatory effects in an individual fashion.
In:
volume:60
In:
number:12
In:
year:2016
In:
pages:2529-2541
In:
extent:13
In:
Molecular nutrition & food research, Weinheim : Wiley-VCH, [2004]-, 60, Heft 12 (2016), 2529-2541 (gesamt 13), 1613-4133
Language:
English
DOI:
10.1002/mnfr.201600328
URN:
urn:nbn:de:101:1-2022111205422334869644
URL:
https://doi.org/10.1002/mnfr.201600328
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2022111205422334869644
URL:
https://d-nb.info/1272604632/34
URL:
https://doi.org/10.1002/mnfr.201600328
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