Format:
7
ISSN:
1550-6606
Content:
In the early phase of an immune response, T cells are activated and acquire effector functions. Whereas these short term activated T cells are resistant to CD95-mediated apoptosis, activated T cells in prolonged culture are readily sensitive, leading to activation-induced cell death and termination of the immune response. The translation inhibitor, cycloheximide, partially overcomes the apoptosis resistance of short term activated primary human T cells. Using this model we show in this study that sensitization of T cells to apoptosis occurs upstream of mitochondria. Neither death-inducing signaling complex formation nor expression of Bcl-2 proteins is altered in sensitized T cells. Although the caspase-8 inhibitor c-FLIPlong was only slightly down-regulated in sensitized T cells, c-FLIPshort became almost undetectable. This correlated with caspase-8 activation and apoptosis. These data suggest that c-FLIPshort, rather than c-FLIPlong, confers resistance of T cells to CD95-mediated apoptosis in the context of immune responses.
Note:
Im Titel ist "short" bei c-FLIP tiefgestellt
,
Gesehen am 04.03.2021
In:
The journal of immunology, Bethesda, Md. : Soc., 1916, 172(2004), 4 vom: 15. Feb., Seite 2194-2200, 1550-6606
In:
volume:172
In:
year:2004
In:
number:4
In:
day:15
In:
month:02
In:
pages:2194-2200
In:
extent:7
Language:
English
DOI:
10.4049/jimmunol.172.4.2194
URL:
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