Format:
Online-Ressource (XI, 500 p, digital)
ISBN:
9783540351092
Series Statement:
Handbook of Experimental Pharmacology 178
Content:
Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.
Content:
Provides comprehensive information on methods for conditional mutagenesis in the mouse and their application to model human physiology and pathophysiology. This book illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms
Note:
Includes bibliographical references and index
,
Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases; Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome; Tetracycline-Controlled Genetic Switches; Novel Gene Switches; Improved Embryonic Stem Cell Technologies; Gene Trap Mutagenesis; RNA Interference in Mice; Viral Vectors: A Wide Range of Choices and High Levels of Service; Conditional Mutagenesis by Cell-Permeable Proteins: Potential, Limitations and Prospects; Analysis of Mouse Development with Conditional Mutagenesis; Conditional Mouse Models of Cancer
,
Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease ModelsConditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory; A Novel Conditional Knockout Strategy Applied to Serotonin Receptors; Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopathy; Animal Models in Cardiovascular Diseases: New Insights from Conditional Models; Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders
,
Conditional Mouse Models to Study Developmental and Pathophysiological Gene Function in MuscleAnalysis of Calcium Channels by Conditional Mutagenesis; Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins; Contribution of Targeted Conditional Somatic Mutagenesis to Deciphering Retinoid X Receptor Functions and to Generating Mouse Models of Human Diseases
Additional Edition:
ISBN 9783540351085
Additional Edition:
Buchausg. u.d.T. Handbook of experimental pharmacology ; Vol. 178: Conditional mutagenesis Berlin : Springer, 2007 ISBN 3540351086
Additional Edition:
ISBN 9783540351085
Language:
English
Subjects:
Biology
,
Medicine
Keywords:
Krankheit
;
Tiermodell
;
Mutagenese
;
Mutagenese
;
Ätiologie
;
Krankheit
;
Tiermodell
;
Mutagenese
;
Ätiologie
;
Aufsatzsammlung
DOI:
10.1007/978-3-540-35109-2
URL:
Volltext
(lizenzpflichtig)
Author information:
Feil, Robert 1966-
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