Format:
Online-Ressource
ISSN:
1521-3765
Content:
Abstract: We have developed an induced circular dichroism (ICD) probe with a chromophore‐linked alkynyldeoxyribose skeleton for analyzing higher‐order structures of DNA duplexes in the visible‐light region. When CG‐repeated oligonucleotides (ODNs) with the probe at their 5′ ends adopted Z‐form duplexes at a high NaCl concentration, strong ICD signals were observed at the absorptive region of the chromophore. On the other hand, their B‐form duplexes, formed at a low NaCl concentration, produced a faint ICD signal. The specific ICD for the Z‐form duplexes was found to appear only when the chromophores were attached at the 5′ ends of each of the ODNs. Furthermore, the chromophoric alkynylnucleoside residues effectively promoted the B to Z transition of the ODN.
In:
volume:16
In:
number:8
In:
year:2010
In:
pages:2401-2406
In:
extent:6
In:
Chemistry - a European journal, Weinheim : Wiley-VCH, 1995-, 16, Heft 8 (2010), 2401-2406 (gesamt 6), 1521-3765
Language:
English
DOI:
10.1002/chem.200902882
URN:
urn:nbn:de:101:1-2023041817314220812361
URL:
https://doi.org/10.1002/chem.200902882
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023041817314220812361
URL:
https://d-nb.info/1286549892/34
URL:
https://doi.org/10.1002/chem.200902882
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