Format:
Online-Ressource (VIII, 299 p. 23 illus., 19 illus. in color, online resource)
ISBN:
9789401787543
Series Statement:
SpringerLink
Content:
This volume explores the latest developments in a novel area of molecular biology and a hot topic in the field of oncology: cancer stem cells. These chapters from expert contributing authors present concepts such as the universal stem cell, new molecular pathways, new targeted agents, the different roles that cancer stem cells seem to have according to the organ they are placed in, and the future role that targeting cancer stem cells may have in the management of patients in the clinic.Exploring the latest research including new data from randomized trials, this book examines important proposals over the origin of cancer stem cells such as the possibility that cancer stem cells may arise from mutated stem cells or a fully differentiated cell that may undergo several mutations that drive it back to a stem-like state. The authors consider the role that stem cells seem to have in the onset, development and resistance to classical antitumoral treatments of cancer and discuss possible potential future treatment modalities for the management of advanced cancer patients.The question, 'Are stem cells involved in cancer?' may not have a simple answer, but ongoing investigations, in-depth consideration and a broad spectrum of information can be found in this book, allowing the reader to arrive at his or her own answer.This book will appeal to researchers in the field of oncology and cancer research and biomedical scientists with an interest in stem cells.
Note:
Description based upon print version of record
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Foreword; Contents; Chapter 1: The Universal Stem Cell Source: Does It Exist?; 1.1 Introduction; 1.2 Concept of Stem Cells; 1.2.1 Stem Cell Types; 1.2.2 Origin of Stem Cells; 1.2.2.1 Embryonic Stem Cells; 1.2.2.2 Adult Stem Cells; 1.2.3 Self-Renewal; 1.2.4 Plasticity; 1.3 Bone Marrow Hematopoietic Stem Cells; 1.4 Stem/Progenitors from Outside the Bone Marrow; 1.4.1 Engraftment; 1.4.2 Transdifferentiation; 1.4.3 Cell-Cell Fusion; 1.5 The Primary Niche; 1.5.1 Tissue-Specific Adult Stem Cells; 1.5.2 The Niche Aging; 1.6 The Secondary Niche; 1.6.1 Bone Marrow Cells: Within Bone and Beyond
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1.6.2 Bone Marrow: Home for Hematopoiesis and Source for Migrating for Secondary Niche1.6.3 Labeled Retained Cells (LRC); 1.6.4 The Niche Stroma; 1.7 Plasticity of BM Outside the BM; 1.7.1 Bone Marrow-Derived Cells Recruited to the Secondary Niche ; 1.7.2 Marrow to Liver (Hepatocyte); 1.7.3 Marrow to Muscle Cardiomyocites; 1.7.4 Marrow to Lung; 1.7.5 Marrow to Brain (Astrocytes); 1.7.6 Marrow to Kidney (Glomerular Mesangial) Cells; 1.7.7 Marrow to Skin; 1.7.8 Marrow to Gastrointestinal Tract; Conclusions; References
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Chapter 2: What Is the Meaning of Notch Pathway and How Can We Selectively Do the Targeting?2.1 Introduction; 2.2 Notch Signaling Pathway; 2.3 Notch Pathway Functions in Normal and Cancerous Cells: Rationale for Notch Inhibition in Cancer; 2.4 Notch Signaling in Hematologic and Solid Tumors; 2.4.1 Notch Signaling in T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphomas; 2.4.2 Notch Signaling in Solid Tumors; 2.4.2.1 Breast Cancer; 2.4.2.2 Colon Cancer; 2.4.2.3 Pancreatic Cancer; 2.4.2.4 Medulloblastoma; 2.4.2.5 Skin Tumors; 2.5 Therapeutic Approaches to Modulating Notch Signaling; 2.5.1 GSIs
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2.5.1.1 GSI for Notch-Targeted Cancer Therapeutics: T-ALL and Other Hematologic Malignancies2.5.1.2 GSI-Based Therapies for Solid Tumors; 2.5.2 Notch Immunotherapy: Antibody Inhibitors of Notch Activity; 2.5.3 Peptide-Based Approaches; 2.5.4 Combinatorial Therapies Involving Notch Inhibition; 2.5.5 Future Approaches for Notch Inhibition; 2.5.5.1 Other Potential Approaches to Small-Molecule Inhibitors; 2.5.5.2 Genetic Strategies; 2.5.6 Potential Risks of Notch Inhibition; 2.6 Conclusions and Future Perspectives; References; Chapter 3: Hedhehog as a New Paradigm in Cancer Treatment
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3.1 Introduction3.2 Hedgehog Signalling Pathway; 3.2.1 The Hedgehog Signaling Pathway Cross-Talk with Other Cell Regulator Pathways; 3.2.2 Hedgehog in Cancer; 3.3 Cancer Treatment with Hedgehog Inhibitors; 3.3.1 GDC-0449 (Vismodegib®); 3.3.2 LDE225; 3.3.3 IPI-926; 3.3.4 BMS-833923; 3.3.5 GANT61; 3.3.6 Other Hedgehog Signalling Inhibitors; 3.4 Nutraceuticals: A New Class of Regulators of Hedgehog Signaling; 3.4.1 Curcumin; 3.4.2 Soy Isoflavones; 3.4.3 Epigallocatechin-3 Gallate (EGCG); 3.4.4 Resveratrol; 3.4.5 Vitamin D; Conclusion; Bibliography
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Chapter 4: Wnt Pathway at a Glance: From the Deep of the Crypts to the Current Ways of Targeting
Additional Edition:
ISBN 9789401787536
Additional Edition:
Druckausg. Stem cells in cancer Dordrecht [u.a.] : Springer, 2014 ISBN 9789401787536
Language:
English
Keywords:
Krebs
;
Stammzelle
DOI:
10.1007/978-94-017-8754-3
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