UID:
(DE-602)gbv_1651917221
Format:
Online-Ressource (XVIII, 291 p. 77 illus., 62 illus. in color, digital)
ISBN:
9781461414452
Series Statement:
Advances in Experimental Medicine and Biology 734
Content:
This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling.
Content:
This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling
Note:
Description based upon print version of record
,
Systems Biology ofTumor Dormancy; Foreword; Introduction; Preface; Contents; Contributors; Part I: Angiogenesis; Chapter 1: Genes and Regulatory Pathways Involved in Persistence of Dormant Micro-tumors; Introduction; Dormant Primary Tumors; Experimental In Vivo Models of Human Tumor Dormancy: How Can You Measure what You can't See?; Angiogenesis Regulation of Tumor Dormancy; Molecular Signature of Tumor Dormancy; Future Direction: What Needs to be Changed?; References; Chapter 2: The Host Support Niche as a Control Point for Tumor Dormancy: Implications for Tumor Development and Beyond
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IntroductionThe Bottlenecks of Tumor Dormancy; The Post-vascular Dormant Tumor; A Dynamic Carrying Capacity Representation for Angiogenesis-Dependent Tumor Growth; The Mathematics of Control of Distant Metastases; Human Cancers; Conclusion; References; Chapter 3: Insights into the Regulation of Tumor Dormancy by Angiogenesis in Experimental Tumors; Aim of the Chapter; The Angiogenic Switch and Tumor Dormancy; Angiogenesis Triggers Both Positive and Negative Regulatory Signals in Tumor Cells: Implications for the Homeostasis of Cancer Stem Cells
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Counteracting the Angiogenic Switch with Anti-VEGF Drugs: Implications for Tumor DormancyConclusions; References; Part II: Stem Cells and Signaling Pathways; Chapter 4: Cancer Stem Cells and Tumor Dormancy; Introduction; Cancer Stem Cells and Non-stem Cancer Cells; An Agent-Based Model of Cancer Stem Cell-Initiated Tumor Growth; A Homogeneous Population of Cancer Stem Cells; A Homogeneous Population of Non-Stem Cancer Cells and Tumor Dormancy; Tumor Dormancy in Heterogeneous Tumors; Discussion; References; Chapter 5: Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy
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IntroductionEarly Dissemination as a Contributing Factor to Dormancy and MRD; The Target Organ Microenvironment and DTC Dormancy; ER-Stress Signaling Pathways Contribute to Growth Arrest and Survival Programs During Tumor Cell Dormancy; Autophagy and Survival of Residual Disease; Concluding Remarks; References; Chapter 6: Tumor Dormancy, Oncogene Addiction, Cellular Senescence, and Self-Renewal Programs; Oncogene Addiction: A Mechanism of Tumor Regression; Oncogene Addiction, Tumor Dormancy, Senescence, and Self-renewal Programs
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Oncogene Addiction, Tumor Dormancy, and the Tumor MicroenvironmentImmune Effectors and Tumor Dormancy Versus Elimination; Therapeutic Implications: Tumor Dormancy Versus Elimination; Modeling and Predicting Tumor Dormancy Versus Elimination; Summary; References; Part III: Immune System; Chapter 7: Multifaceted Kinetics of Immuno-Evasion from Tumor Dormancy; Introduction; Case Study 1: Mathematical Modeling of Immuno-Editing: Tumor Evasion at Large Timescales; The Kuznetsov Model of Tumor-Immune System Interplay; Modeling Immuno-Escape; Simulations
,
Case Study 2: Modeling the Mesoscale Immuno-Evasion of a ``Dormant'' Tumor
,
Foreword -- Preface -- Part 1: Angiogenesis -- Genes and Regulatory Pathways Involved in Persistence of Dormant Micro-Tumors -- The Host Support Niche as a Control Point for Tumor Dormancy - Implications for Tumor Development and Beyond -- Insights into the Regulation of Tumor Dormancy by Angiogenesis in Experimental Tumors -- Part 2: Stem Cells and Signaling Pathways -- Cancer Stem Cells and Tumor Dormancy -- Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy -- Tumor Dormancy, Oncogene Addiction, Cellular Senescence and Self Renewal Programs -- Part 3: Immune System -- Multifaceted Kinetics of Immuno-Evasion from Tumor Dormancy -- Tumor Dormancy and Cancer Stem Cells: Two Sides of the Same Coin? -- Tumor Dormncy: Long-Term Survival in a Hostile Environment -- A Review of Mathematical Models of Cancer-Immune Interactions in the Context of Tumor Dormancy -- Part 4: Mathematical Biosciences and Dynamical Systems Modeling -- Regulation of Tumor Dormancy and Role of Microenvironment: A Mathematical Model -- Seeing the Invisible -- How Mathematical Models Uncover Tumor Dormancy, Reconstruct the Natural History of Cancer, and Assess the Effects of Treatment -- Index.
Additional Edition:
ISBN 9781461414445
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-461-41444-5
Language:
English
DOI:
10.1007/978-1-4614-1445-2
URL:
Volltext
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