Format:
Online-Ressource (211 p)
ISBN:
9783709106860
Content:
This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions
Note:
Description based upon print version of record
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Foreword; Preface; Contents; Contributors; Abbreviations; 1: Historical Review; 1.1 Historical Roots; 1.2 Development of MSA Experimental Models; 1.3 Consensus on Diagnostic Criteria; 1.4 Worldwide MSA Study Groups; 1.5 Perspectives; 1.6 MSA Communities and Support Groups; References; 2: Epidemiology; 2.1 Epidemiology; References; 3: Neuropathology; 3.1 Macroscopy; 3.2 Histopathology; 3.2.1 Distribution of Pathology; 3.2.2 Involvement of the Autonomic Nervous System; 3.2.3 Involvement of the Peripheral Nervous System; 3.2.4 White Matter Lesions; 3.3 Inclusion Pathology
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3.3.1 Distribution of Inclusions3.3.2 Composition of GCIs; 3.3.3 Ultrastructure of Cellular Inclusions; 3.3.4 Glial Reactions; 3.4 Staging Schemes for MSA; 3.5 Concomitant Pathologies; References; 4: Aetiopathogenesis; General; 4.2 αSyn in MSA; 4.3 Tau in MSA; 4.4 Oxidative Stress and Mitochondrial Dysfunction; 4.5 Neuroinflammation in MSA; 4.6 Working Hypothesis for the Pathogenesis of MSA; 4.7 Future Directions; 4.8 Genetics; 4.8.1 Familial MSA; 4.8.2 Risk Loci; References; 5: Animal Models; 5.1 General; 5.1.1 Toxin Models; 5.1.2 Transgenic Models
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5.2 Experimental Interventions in Animal Models of MSA5.2.1 Neurotransplantation; 5.2.2 Neuroprotection; 5.3 Future Perspectives; References; 6: Clinical Presentation; 6.1 Presenting Features; 6.2 Parkinsonism; 6.3 Cerebellar Signs; 6.4 Speech Impairment; 6.5 Autonomic Failure; 6.5.1 Urogenital Dysfunction; 6.5.2 Cardiovascular Autonomic Failure; 6.5.3 Respiratory Dysfunction; 6.5.4 Gastrointestinal Dysfunction; 6.5.5 Other Features of Autonomic Failure; 6.6 Pyramidal Signs; 6.7 "Red Flags"; 6.7.1 Rapid Clinical Deterioration; 6.7.2 Early Postural Instability; 6.7.3 Abnormal Postures
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6.7.4 Bulbar Dysfunction6.7.5 Respiratory Dysfunction; 6.7.6 Emotional Incontinence; 6.8 Cognition in MSA; 6.9 Behaviour in MSA; 6.10 Sleep Disturbances in MSA; 6.10.1 REM Sleep Behaviour Disorder (RBD); 6.10.2 Reduced and Fragmented Sleep; 6.10.3 Excessive Daytime Sleepiness; 6.10.4 Restless Legs Syndrome; 6.10.5 Sleep-Disordered Breathing; 6.11 Pain in MSA; References; 7: Clinical Diagnostic Criteria; 7.1 Background; 7.1.1 Quinn's Criteria for the Diagnosis of MSA: 1989; 7.1.2 1st Consensus Statement on the Diagnosis of MSA: 1998; 7.2 2nd Consensus Statement on the Diagnosis of MSA: 2008
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7.2.1 Definite MSA7.2.2 Probable MSA; 7.2.3 Possible MSA; 7.2.4 Red Flags; 7.3 Other Diagnostic Criteria for MSA; 7.3.1 Scoring Systems; 7.3.2 NNIPPS Criteria; References; 8: Natural History; 8.1 Disease Progression; 8.2 Clinical Milestones; 8.3 Prognosis; 8.3.1 Mean Survival; 8.3.2 Causes of Death; 8.3.3 Negative Prognostic Factors; 8.3.4 Positive Prognostic Factors; 8.4 The Prognostic Role of Cardiovascular Autonomic Failure; 8.5 Premotor MSA; References; 9: Investigations; 9.1 Autonomic Function Tests; 9.1.1 Cardiovascular Function; 9.1.2 Bladder Function; 9.1.3 Gastrointestinal Function
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9.1.4 Sudomotor Function
Additional Edition:
9783709106877
Additional Edition:
9783709106860
Additional Edition:
Print version Multiple System Atrophy
Language:
English
Keywords:
Electronic books
URL:
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