In:
International Journal of Cancer, Wiley, Vol. 139, No. 8 ( 2016-10-15), p. 1740-1743
Abstract:
What's new? Hemochromatosis causes iron overload, resulting in increased oxidative stress and potentially fueling the proliferation of tumor cells. It remains unclear, however, whether iron overload promotes cancer development in hemochromatosis patients. In this population‐based study involving nearly 7,000 hemochromatosis patients in Sweden, the iron disorder was strongly associated with liver cancer and was linked to increased risk of esophageal squamous cell carcinoma and colon cancer. No association was found for gastric or rectal cancers, however. Further investigation of a possible role for iron overload in the development of non‐hepatic gastrointestinal cancer is needed.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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