In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 32, No. 7-8 ( 2018-04-01), p. 491-496
Abstract:
Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 ( Nf1 ) optic LGG stem cells (o-GSCs) form glioma-like lesions in wild-type, but not athymic, mice following transplantation. Here, we show that the inability of athymic mice to support o-GSC engraftment results from impaired microglia/macrophage function, including reduced expression of Ccr2 and Ccl5, both of which are required for o-GSC engraftment and Nf1 optic glioma growth. Impaired Ccr2 and Ccl5 expression in athymic microglia/macrophages was restored by T-cell exposure, establishing T-cell–microglia/macrophage interactions as critical stromal determinants that support NF1 LGG growth.
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
DOI:
10.1101/gad.310797.117
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2018
detail.hit.zdb_id:
1467414-2
SSG:
12
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