Kooperativer Bibliotheksverbund

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Format: 1 Online-Ressource

ISBN: 9781441972194

Content: This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).

Additional Edition: Erscheint auch als Druckausgabe ISBN 978-1-4419-7218-7

Language: English

Subjects: Biology

DOI: 10.1007/978-1-4419-7219-4

URL: Volltext

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Format: Online-Ressource (220 p.)

ISBN: 9781587062858

Content: Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregat

Note: Description based upon print version of record , COVER; Title Page. Interleukin-10; Copyright ©2006; Table of Contents; Editor and Contributors; Preface; CHAPTER 1A. Structure and Function of IL-10 and the IL-10 Receptor; CHAPTER 1B. IL-10 Effects on Innate Immunity; CHAPTER 1C. Interleukin-10 and Adaptive Immune Response; CHAPTER 2. Experimental Models for the Analysis of IL-10 Function; CHAPTER 3A. Role of IL-10 in Autoimmune Pathology; CHAPTER 3B. Interleukin-10 Gene Polymorphisms and Cancer; CHAPTER 3C. IL-10 Gene Polymorphisms in Transplantation; CHAPTER 3D. IL-10, Genetic Polymorphism and Its Relevance to Age-Related Diseases , CHAPTER 4. IL-10: Role in Infectious DiseasesCHAPTER 5. Interleukin-10 in Allergic Disease; CHAPTER 6. The Role of IL-10 in Autoimmune Pathology; CHAPTER 7. Role of Interleukin-10 in Transplantation; CHAPTER 8A. Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis; CHAPTER 8B. Interleukin-10 and Psoriasis; CHAPTER 8C. IL-10: The Role in Crohn's Disease; CHAPTER 8D. IL-10 and Systemic Lupus Erythematosus; CHAPTER 9. Role of IL-10 in Cancer; INDEX; BACK COVER;

Additional Edition: 9781587063756

Additional Edition: Print version Interleukin-10

Language: English

Keywords: Electronic books

URL: Volltext

UID:

Format: 1 electronic text (186 p.) , col. ill., digital file

ISBN: 9781780840321 , 9781780840338

Series Statement: Future Science Group eBook collection

Note: Includes bibliographical references and index

Language: English

Subjects: Medicine

Keywords: Melanom ; Therapie

DOI: 10.2217/9781780840321

URL: Volltext

UID:

Format: VII, 353 S. , graph. Darst.

ISBN: 9781441972187

Language: English

Subjects: Biology

UID:

Format: 1 online resource (350 pages)

ISBN: 9781441972194

Content: This book discusses the mechanisms leading to immune-mediated tissue rejection. It follows the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple.

Content: Intro -- Immunologic Signaturesof Rejection -- Contents -- Part I: Preamble -- From the "Delayed Allergy Reaction" to the "Immunologic Constant of Rejection" -- From the Delayed Allergy Reaction to the Immunologic Constant of Rejection -- Interferon Regulatory Factor (IRF)-1: Master Switch of Inflammation -- The Recurrent Themes Defining the Signatures of Rejection -- References -- Part II: The Immune Biology of Rejection:Basic Principles -- The Yin Yang of Cancer RelatedInflammation -- Introduction -- Recruitment of TAM -- Plasticity of TAM and Promotion of Metastasis -- Protective Inflammation and Macrophage Activation -- References -- The Immune Rejection: Lessonsfrom Experimental Models -- Introduction -- Rejection of Intestinal Microbiota -- Rejection of Acute Infections -- Chronic Inflammation in Obesity -- Tumor Rejection -- Concluding Remarks -- References -- Turning on and off the Immunological Switch: Immune Response Polarization and Its Control by IL-10 and STAT3 -- T Helper Cell Lineages -- Differentiation and Activation of T Helper Lineages -- Function and Plasticity of Th and Treg Lineages In Vivo -- IL-10 Controls Inflammation -- Regulation of IL-10 Production -- IL-10 Signaling and Role of STAT3 in its Regulatory Functions -- IL-10 has Superior Anti-Inflammatory Activity Compared with Other STAT3-Signaling Cytokines: Role of SOCS3 -- Molecular Mechanisms of the IL-10-Mediated Anti-Inflammatory Effects -- Roles of STAT3 in Health and Disease -- Roles of STAT3 in Cancer -- STAT3 and IL-10 in Cancer-Promoting Inflammation -- IL-10 Inhibition Facilitates Immune Responses to Tumors -- Targeting STAT3 Facilitates Anti-Tumor Immune Responses -- Conclusions -- References -- The Angiogenic Switch: Role of Immune Cells -- Introduction -- Innate Immunity -- Macrophages and the Macrophage Polarization Paradigm.

Note: Description based on publisher supplied metadata and other sources

Additional Edition: 9781489982438

Additional Edition: Erscheint auch als Druck-Ausgabe 9781489982438

Language: English

URL: lizenzpflichtig

UID:

Format: XXIII, 712 S. , ill. (some col.)

ISBN: 1627037276 , 9781627037273 , 1627037268 , 9781627037266

Series Statement: Methods in molecular biology 1102

Note: Includes bibliographical references and index , Novel insights/translational implication from the emerging biology of melanoma , Emerging clinical issues in melanoma in the molecularly targeted era , Integrating molecular biomarkers into current clinical management in melanoma , Advances in adjuvant therapy : potential for prognostic and predictive biomarkers , Immunologic monitoring of cancer vaccine trials using the ELISPOT assay , Markers for anti-cytotoxic T-lymphocyte antigen 4 (CTLA- 4) therapy in melanoma , Marker utility for combination therapy , Assaying for BRAF V600E in tissue and blood in melanoma , Selecting patients for KIT inhibition in melanoma , Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma , Current status of diagnostic and prognostic markers in melanoma , Chromosomal copy number analysis in melanoma diagnostics , Construction and analysis of multiparameter prognostic models for melanoma outcome , Immunohistochemical diagnostic and prognostic markers for melanoma , Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma , Tumor-infiltrating lymphocytes and their significance in melanoma prognosis , Pathological staging of melanoma , Genotyping of human leukocyte antigen (HLA) ancestral haplotypes as prognostic marker in cancer using PCR analysis , B7-H abnormalities in melanoma and clinical relevance , Melanoma susceptibility genes and risk assessment , Clinical, pathologic, and imaging features and biological markers of uveal melanoma , Prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile , Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma , ERBB4 mutation analysis : emerging molecular target for melanoma treatment , Epigenetic markers of prognosis in melanoma , Isolation of melanoma cell subpopulations using negative selection , Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients , Detection of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma , Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma , Clinical use of PET/CT in the evaluation of melanoma , Immune system functional pathway analysis using single cell network profiling (SCNP) : a novel tool in cancer immunotherapy , Detection of circulating tumor cells by photoacoustic flowmetry , Statistical design and evaluation of biomarker studies , Tissue resources for clinical use and marker studies in melanoma

Additional Edition: 9781627037273

Additional Edition: Online-Ausg. Thurin, Magdalena Molecular Diagnostics for Melanoma Totowa, NJ : Humana Press, 2014 9781627037273

Language: English

Subjects: Medicine

Keywords: Melanom ; Diagnostik

URL: Cover

URL: Inhaltsverzeichnis

UID:

Format: 1 Online-Ressource (XII, 314 Seiten)

Edition: 1st ed. 2005

ISBN: 9781402036231 , 140203623X , 9048103967 , 9048169119 , 1402036221

Additional Edition: Erscheint auch als Druck-Ausgabe Analyzing T Cell Responses Dordrecht : Springer Netherlands, 2005 9789048103966

Additional Edition: 9789048103966

Additional Edition: 9789048169115

Additional Edition: 9781402036224

Language: English

DOI: 10.1007/1-4020-3623-X

URL: https://doi.org/10.1007/1-4020-3623-X

URL: Inhaltsverzeichnis

URL: Ausführliche Beschreibung

UID:

Format: 1 Online-Ressource (XXIII, 712 p. 110 illus., 94 illus. in color)

ISBN: 9781627037273

Series Statement: Methods in Molecular Biology, Methods and Protocols 1102

Content: In Molecular Diagnostics for Melanoma: Methods and Protocols, expert researchers and clinicians in the field of melanoma provide updated information on biomarkers and assays for diagnosis, prognosis, and assays predicting response to treatment for routine testing. The focus of the volume is on biomarkers with established clinical validity rather than those on early discovery stage.  With additional in-depth discussion of the molecular biology and pathology of melanoma, treatment options in adjuvant and metastatic setting, and implications of biomarker testing for clinical management of melanoma patients.   Written in the highly successful Methods in Molecular Biology series format, chapters include extensive introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.   Comprehensive and practical, Molecular Diagnostics for Melanoma: Methods and Protocols seeks to provide both clinicians and scientists with technical information and extensive background information on the wide ranging approaches available in the field of diagnostics of melanoma

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781627037266

Language: English

Keywords: Melanom ; Diagnostik

DOI: 10.1007/978-1-62703-727-3

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: Online-Ressource (VII, 300p. 21 illus., 19 illus. in color, digital)

ISBN: 9781441972194

Series Statement: SpringerLink

Content: This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).

Note: Includes bibliographical references and index , Immunologic Signaturesof Rejection; Contents; Part I:Preamble; From the "Delayed Allergy Reaction" to the "Immunologic Constant of Rejection"; From the Delayed Allergy Reaction to the Immunologic Constant of Rejection; Interferon Regulatory Factor (IRF)-1: Master Switch of Inflammation; The Recurrent Themes Defining the Signatures of Rejection; References; Part II:The Immune Biology of Rejection:Basic Principles; The Yin Yang of Cancer RelatedInflammation; Introduction; Recruitment of TAM; Plasticity of TAM and Promotion of Metastasis; Protective Inflammation and Macrophage Activation , ReferencesThe Immune Rejection: Lessonsfrom Experimental Models; Introduction; Rejection of Intestinal Microbiota; Rejection of Acute Infections; Chronic Inflammation in Obesity; Tumor Rejection; Concluding Remarks; References; Turning on and off the Immunological Switch: Immune Response Polarization and Its Control by IL-10 and STAT3; T Helper Cell Lineages; Differentiation and Activation of T Helper Lineages; Function and Plasticity of Th and Treg Lineages In Vivo; IL-10 Controls Inflammation; Regulation of IL-10 Production; IL-10 Signaling and Role of STAT3 in its Regulatory Functions , IL-10 has Superior Anti-Inflammatory Activity Compared with Other STAT3-Signaling Cytokines: Role of SOCS3Molecular Mechanisms of the IL-10-Mediated Anti-Inflammatory Effects; Roles of STAT3 in Health and Disease; Roles of STAT3 in Cancer; STAT3 and IL-10 in Cancer-Promoting Inflammation; IL-10 Inhibition Facilitates Immune Responses to Tumors; Targeting STAT3 Facilitates Anti-Tumor Immune Responses; Conclusions; References; The Angiogenic Switch: Role of Immune Cells; Introduction; Innate Immunity; Macrophages and the Macrophage Polarization Paradigm; Tumor Associated Macrophages (TAMs) , Tie2 Expressing MacrophagesMyeloid Derived Suppressor Cells (MDSCS); Granulocytes; Mast Cells; Dendritic Cells; DCs and Angiogenesis; NK Cells; NK Localization; Specific Immunity; Conclusions; References; Chemokines and Cytotoxic Effector Molecules in Rejection; Chemokines; Translation to Clinical Utility; Cytotoxic Effector Molecules; Conclusion; References; Clinical Applications of Activated Immune Cells; Introduction; Immune Therapy for Viral Infections; Cytomegalovirus; Immune Therapy for Viral Induce Malignancies; Posttransplant EBV-Associated Lymphoproliferative Disease , Immune Therapy for LeukemiaDonor Leukocyte Infusions; NK Cells; Immune Therapy for Cancer; Tumor Infiltrating Leukocytes for Melanoma; Dendritic Cells; New Directions; References; Part III:Circulating Patterns Associated with Chronic and Acute Immune Pathology; Blood Transcriptional Fingerprints to Assess the Immune Status of Human Subjects; Blood Transcript Profiling; Profiling Human Subjects in Health and Disease; Profiling Autoimmune Diseases; Profiling Infectious Diseases; Profiling other Diseases; Technology Primer (Fig. 1); Microarray Data Analysis; Analysis Primer , Analysis of Significance Patterns

Additional Edition: 9781441972187

Additional Edition: Buchausg. u.d.T. 978-1-441-97218-7

Language: English

Subjects: Biology

DOI: 10.1007/978-1-4419-7219-4

URL: Volltext

URL: Volltext  (lizenzpflichtig)

UID:

Format: Online-Ressource

ISBN: 9781441972194

Note: Lizenzpflichtig

Additional Edition: Druckausg. Immunologic Signatures of Rejection New York, NY : Springer New York, 2010

Language: German

DOI: 10.1007/978-1-4419-7219-4

URN: urn:nbn:de:1111-20101103537

URL: https://doi.org/10.1007/978-1-4419-7219-4

URL: https://nbn-resolving.org/urn:nbn:de:1111-20101103537

URL: https://d-nb.info/1008057606/34

URL: http://www.springerlink.com/content/978-1-4419-7219-4