In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 9 ( 2001-04-24), p. 5104-5109
Abstract:
Ewes from the Booroola strain of Australian Mérino sheep are
characterized by high ovulation rate and litter size. This phenotype is due to the action of the FecB B allele of a major gene named FecB , as
determined by statistical analysis of phenotypic data. By genetic analysis of 31 informative half-sib families from heterozygous sires,
we showed that the FecB locus is situated in the region
of ovine chromosome 6 corresponding to the human chromosome 4q22–23 that contains the bone morphogenetic protein receptor IB
( BMPR-IB ) gene encoding a member of the transforming
growth factor-β (TGF-β) receptor family. A nonconservative substitution (Q249R) in the BMPR-IB coding sequence was
found to be associated fully with the hyperprolificacy phenotype of Booroola ewes. In vitro , ovarian granulosa cells from FecB B / FecB B ewes were less responsive than granulosa cells from FecB + / FecB + ewes to the inhibitory effect on steroidogenesis of GDF-5 and BMP-4,
natural ligands of BMPR-IB. It is suggested that in FecB B / FecB B ewes, BMPR-IB would be inactivated partially, leading to an advanced
differentiation of granulosa cells and an advanced maturation of ovulatory follicles.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.091577598
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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