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  • 1
    Online Resource
    Online Resource
    Breast Cancer in Women of African Descent (2006)
    Dordrecht : Springer Netherlands | Cham : Springer International Publishing AG
    Details
    UID:
    (DE-603)224768913
    Format: 1 Online-Ressource (XXII, 384 Seiten)
    Edition: 1st ed. 2006
    ISBN: 9781402036644 , 1402036647 , 904811778X , 9048169291 , 1402036825
    Additional Edition: Erscheint auch als Druck-Ausgabe Breast Cancer in Women of African Descent Dordrecht : Springer Netherlands, 2006 9789048117789
    Additional Edition: 9789048117789
    Additional Edition: 9789048169290
    Additional Edition: 9781402036828
    Language: English
    DOI: 10.1007/978-1-4020-3664-4
    URL: https://doi.org/10.1007/978-1-4020-3664-4
    URL: Inhaltsverzeichnis
    URL: Ausführliche Beschreibung
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  • 2
    Online Resource
    Online Resource
    Breast Cancer in Women of African Descent (2010)
    Dordrecht : Springer
    Details
    UID:
    (DE-627)769479294
    Format: Online-Ressource (394 p)
    ISBN: 9781402036828
    Content: Although there are numerous technical-scientific books on breast cancer in the global bibliography, such books deal exclusively with the nature of the disease in majority populations of the Western societies, with little or no reference to the nature of the disease in the minority populations in such societies. Similarly, the nature of breast cancer in black women of the less privileged societies, and in women of ethnic groups living in countries of similar socio-economic status, is virtually unknown. For various epidemiological reasons, breast cancer incidence is rapidly increasing in these c
    Note: Description based upon print version of record , Title Page; Copyright Page; Table of Contents; PREFACE; LIST OF CONTRIBUTORS; ACKNOWLEDGEMENTS; INTRODUCTION; REFERENCES; Chapter 1 BURDEN OF BREAST CANCER IN DEVELOPING AND DEVELOPED COUNTRIES; 1. INTRODUCTION; 1.1 Indices of ""burden""; 2. ESTIMATION; 3. BURDEN 2000; 4. BREAST CANCER INAFRICA; 5. UNITED STATES; 6. CARIBBEAN; 7. BRAZIL; 8. THE FUTURE; REFERENCES; Chapter 2 GENETICS OF BREAST CANCER IN WOMEN OF AFRICAN DESCENT: AN OVERVIEW; 1. EPIDEMIOLOGY; 2. GENETICS; 3. PARALLELS BETWEEN BRCA-ASSOCIATED BREAST CANCERS (BABC) AND BREAST CANCERS IN BLACK WOMEN , 3.1 BRCA1 Mutations in African-Americans3.2 BRCA2 mutations in African-American; 3.3 Polymorphisms/Sequene Variations; 3.4 BRCA1 and BRCA2 Mutations among Africans; 4. FOUNDER MUTATIONSAMONG FAMILIES OF AFRICAN ANCESTRY; 4.1 TP53; 4.2 ATM; 4.3 UGTIAI; 5. GENETIC COUNSELING; 6. CONCLUSION; REFERENCES; Chapter 3 BIOLOGY OF BREAST CANCER; 1. BIOLOGY OF BREAST CANCER - AN OVERVIEW; 2. BREAST CANCER SIZE AND GRADE IN WOMEN OF AFRICAN DESCENT; 3. GENETICS OF FAMILIALAND SPORADIC DUCTAL ADENOCARCINOMAS; 4. MOLECULAR MARKERS IN BREAST CARCINOMA; 4.1 Estrogen and Progesterone Receptors , 4.2 Proliferation4.3 p27Kip-1; 4.4 Cyclin D1; 4.5 Angiogenesis and VEGF; 4.6 Growth Factors and Related Receptors: The Epidermal Growth Factor Receptor Family and Related Proto-oncogenes in Breast Cancer; 4.6.1 Epidermal Growth Factor Receptor and its Ligands; 4.6.2 P185erbB-2 and Breast Cancer; 4.6.3 P180erbB-3 and p180erbB-4 in Breast Cancers; 4.7 Apoptosis and Tumor Suppressor Genes in Breast Cancer; 4.7.1 p53; 4.7.2 Bcl-2; 4.7.3 Bax; 5. SUMMARY; REFERENCES; Chapter 4 SCREENING AND EARLY DETECTION OF BREAST CANCER IN WOMEN IN AFRICA AND THE MIDDLE EAST; 1. OBJECTIVE , 2. INCIDENCE AND MORTALITY3. SCREENING METHODS; 4. INTERNATIONAL RECOMMENDATIONS; 5. CURRENT PRACTICE; 6. CRITICAL ISSUES; 6.1 Socio-economic Status; 6.2 Healthcare System and Funding; 6.3 HIV/AIDS and Life Expectancy in Africa; 6.4 Tuberculosis; 6.5 Cultural Beliefs; 6.5.1 Sangoma; 6.5.2 Inyanga; 6.5.3 Witchdoctors; 7. RECOMMENDATIONS; 7.1 Recommendationsfor Prevention of Advanced Disease; REFERENCES; Chapter 5 BREAST CANCER AT DIAGNOSIS IN WOMEN OF AFRICA AND THE MIDDLE EAST; 1. INTRODUCTION; 2. BREAST CANCER BURDEN IN AFRICA AND THE MIDDLE EAST; 3. DIAGNOSTIC WORKUP , 4. CLINICO-PATHOLOGIC DIAGNOSTIC PROFILE5. SPECIALTYPES AND ASSOCIATIONS; 5.1 Inflammatory Breast Cancer; 5.2 Breast Cancer and HIV Epidemic in African Populations; 5.3 Frequency and Genome Load of EBV in Breast Cancer Cases; 5.4 Factors Responsible for Late Presentation of the Disease in the African Population; REFERENCES; Chapter 6 BREAST CANCER AGGRESSIVENESS INWOMEN OF AFRICAN DESCENT; 1. INTRODUCTION; 2. HISTORICALASPECTS; 3. THE IMPACT OF AGGRESSIVE BREAST CANCER ON AFRICAN-AMERICAN WOMEN; 4. IMPORTANT RESEARCH QUESTIONS IN AFRICAN AMERICAN WOMEN , 4.1 What is the Relative Impact of Tumour Aggressiveness vs. Access to Care on Mortality Rates in African-American Women?
    Additional Edition: 9781402036644
    Additional Edition: Print version Breast Cancer in Women of African Descent
    Language: English
    Keywords: Electronic books
    URL: Volltext
    URL: Volltext
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  • 3
    Online Resource
    Online Resource
    Breast Cancer in Women of African Descent (2006)
    Dordrecht : Springer Netherlands
    Details
    UID:
    (DE-627)164974370X
    Format: Online-Ressource (XXII, 383 p, digital)
    ISBN: 9781402036644
    Series Statement: SpringerLink
    Additional Edition: 9781402036828
    Additional Edition: Buchausg. u.d.T. 978-1-4020-3682-8
    Language: English
    DOI: 10.1007/978-1-4020-3664-4
    URL: Volltext
    URL: Cover
    URL: Inhaltstext
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  • 4
    Online Resource
    Online Resource
    Breast Cancer in Women of African Descent (2006)
    Dordrecht : Springer Science+Business Media B.V.
    Details
    UID:
    (DE-605)TT050384827
    ISBN: 9781402036644
    Additional Edition: Erscheint auch als Druck-Ausgabe 9781402036828
    Language: English
    DOI: 10.1007/978-1-4020-3664-4
    URL: http://dx.doi.org/10.1007/978-1-4020-3664-4
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  • 5
    Online Resource
    Online Resource
    Breast Cancer in Women of African Descent (2006)
    Dordrecht : Springer Science+Business Media B.V
    Details
    UID:
    (DE-627)630430551
    Format: Online-Ressource , v.: digital
    Edition: Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9781402036644
    Content: Although there are numerous technical-scientific books on breast cancer in the global bibliography, such books deal exclusively with the nature of the disease in majority populations of the Western societies, with little or no reference to the nature of the disease in the minority populations in such societies. Similarly, the nature of breast cancer in black women of the less privileged societies, and in women of ethnic groups living in countries of similar socio-economic status, is virtually unknown. For various epidemiological reasons, breast cancer incidence is rapidly increasing in these c
    Note: Description based upon print version of record , Title Page; Copyright Page; Table of Contents; PREFACE; LIST OF CONTRIBUTORS; ACKNOWLEDGEMENTS; INTRODUCTION; REFERENCES; Chapter 1 BURDEN OF BREAST CANCER IN DEVELOPING AND DEVELOPED COUNTRIES; 1. INTRODUCTION; 1.1 Indices of "burden"; 2. ESTIMATION; 3. BURDEN 2000; 4. BREAST CANCER INAFRICA; 5. UNITED STATES; 6. CARIBBEAN; 7. BRAZIL; 8. THE FUTURE; REFERENCES; Chapter 2 GENETICS OF BREAST CANCER IN WOMEN OF AFRICAN DESCENT: AN OVERVIEW; 1. EPIDEMIOLOGY; 2. GENETICS; 3. PARALLELS BETWEEN BRCA-ASSOCIATED BREAST CANCERS (BABC) AND BREAST CANCERS IN BLACK WOMEN , 3.1 BRCA1 Mutations in African-Americans3.2 BRCA2 mutations in African-American; 3.3 Polymorphisms/Sequene Variations; 3.4 BRCA1 and BRCA2 Mutations among Africans; 4. FOUNDER MUTATIONSAMONG FAMILIES OF AFRICAN ANCESTRY; 4.1 TP53; 4.2 ATM; 4.3 UGTIAI; 5. GENETIC COUNSELING; 6. CONCLUSION; REFERENCES; Chapter 3 BIOLOGY OF BREAST CANCER; 1. BIOLOGY OF BREAST CANCER - AN OVERVIEW; 2. BREAST CANCER SIZE AND GRADE IN WOMEN OF AFRICAN DESCENT; 3. GENETICS OF FAMILIALAND SPORADIC DUCTAL ADENOCARCINOMAS; 4. MOLECULAR MARKERS IN BREAST CARCINOMA; 4.1 Estrogen and Progesterone Receptors , 4.2 Proliferation4.3 p27Kip-1; 4.4 Cyclin D1; 4.5 Angiogenesis and VEGF; 4.6 Growth Factors and Related Receptors: The Epidermal Growth Factor Receptor Family and Related Proto-oncogenes in Breast Cancer; 4.6.1 Epidermal Growth Factor Receptor and its Ligands; 4.6.2 P185erbB-2 and Breast Cancer; 4.6.3 P180erbB-3 and p180erbB-4 in Breast Cancers; 4.7 Apoptosis and Tumor Suppressor Genes in Breast Cancer; 4.7.1 p53; 4.7.2 Bcl-2; 4.7.3 Bax; 5. SUMMARY; REFERENCES; Chapter 4 SCREENING AND EARLY DETECTION OF BREAST CANCER IN WOMEN IN AFRICA AND THE MIDDLE EAST; 1. OBJECTIVE , 2. INCIDENCE AND MORTALITY3. SCREENING METHODS; 4. INTERNATIONAL RECOMMENDATIONS; 5. CURRENT PRACTICE; 6. CRITICAL ISSUES; 6.1 Socio-economic Status; 6.2 Healthcare System and Funding; 6.3 HIV/AIDS and Life Expectancy in Africa; 6.4 Tuberculosis; 6.5 Cultural Beliefs; 6.5.1 Sangoma; 6.5.2 Inyanga; 6.5.3 Witchdoctors; 7. RECOMMENDATIONS; 7.1 Recommendationsfor Prevention of Advanced Disease; REFERENCES; Chapter 5 BREAST CANCER AT DIAGNOSIS IN WOMEN OF AFRICA AND THE MIDDLE EAST; 1. INTRODUCTION; 2. BREAST CANCER BURDEN IN AFRICA AND THE MIDDLE EAST; 3. DIAGNOSTIC WORKUP , 4. CLINICO-PATHOLOGIC DIAGNOSTIC PROFILE5. SPECIALTYPES AND ASSOCIATIONS; 5.1 Inflammatory Breast Cancer; 5.2 Breast Cancer and HIV Epidemic in African Populations; 5.3 Frequency and Genome Load of EBV in Breast Cancer Cases; 5.4 Factors Responsible for Late Presentation of the Disease in the African Population; REFERENCES; Chapter 6 BREAST CANCER AGGRESSIVENESS INWOMEN OF AFRICAN DESCENT; 1. INTRODUCTION; 2. HISTORICALASPECTS; 3. THE IMPACT OF AGGRESSIVE BREAST CANCER ON AFRICAN-AMERICAN WOMEN; 4. IMPORTANT RESEARCH QUESTIONS IN AFRICAN AMERICAN WOMEN , 4.1 What is the Relative Impact of Tumour Aggressiveness vs. Access to Care on Mortality Rates in African-American Women?
    Additional Edition: 9781402036828
    Language: English
    DOI: 10.1007/978-1-4020-3664-4
    URL: Volltext  (lizenzpflichtig)
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  • 6
    Online Resource
    Online Resource
    Principles of Molecular Oncology (2004)
    Totowa, NJ : Humana Press
    Details
    UID:
    (DE-604)BV046146643
    Format: 1 Online-Ressource (XXI, 709 p. 45 illus)
    Edition: Second Edition
    ISBN: 9781592596645
    Content: Drawing on four years of significant scientific advances and clinical developments, the editors of Principles of Molecular Oncology, Second Edition, have thoroughly updated the highly praised first edition and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small-molecular-weight compounds. The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a "disease process" involving key regulatory pathways. The second edition reaffirms this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics-expression profiling of genes and proteins-with developmental therapeutics, and the "binary state" concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. Comprehensive and intellectually stimulating, Principles of Molecular Oncology, Second Edition not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much-neglected gap between "information" and "knowledge," and holds out the hope of new anticancer strategies that will reduce cancer cell proliferation and significantly reduce metastasis
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781475762761
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781475762754
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781588292797
    Language: English
    Subjects: Medicine
    RVK:
    XH 1700
    Keywords: Onkologie ; Molekularbiologie
    DOI: 10.1007/978-1-59259-664-5
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 7
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    Online Resource
    Dynamic contrast-enhanced magnetic resonance imaging for risk-stratified screening in women with BRCA mutations or high familial risk for breast cancer: are we there yet? (2020)
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    Details
    UID:
    (DE-101)1217985743
    Format: Online-Ressource , online resource.
    ISSN: 1573-7217 , 1573-7217
    In: volume:183
    In: number:2
    In: day:3
    In: month:7
    In: year:2020
    In: pages:243-250
    In: date:9.2020
    In: Breast cancer research and treatment, Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981-, 183, Heft 2 (3.7.2020), 243-250, 9.2020, 1573-7217
    Language: English
    DOI: 10.1007/s10549-020-05759-3
    URN: urn:nbn:de:101:1-2020092016022935813022
    URL: https://doi.org/10.1007/s10549-020-05759-3
    URL: https://nbn-resolving.org/urn:nbn:de:101:1-2020092016022935813022
    URL: https://d-nb.info/1217985743/34
    URL: https://doi.org/10.1007/s10549-020-05759-3
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  • 8
    Online Resource
    Online Resource
    Principles of Molecular Oncology (2008)
    [s.l.] : Humana Press
    Details
    UID:
    (DE-627)658603647
    Format: Online Ressource (8521 KB, 429 S.)
    Edition: 3. Aufl.
    Edition: Online-Ausg. 2009 Electronic reproduction; Available via World Wide Web
    ISBN: 1934115258
    Content: Drawing on years of significant advances and developments, the editors of this third edition have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules.
    Content: Drawing on years of significant scientific advances and clinical developments, the editors of POMO III have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules. The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a disease process involving key regulatory pathways. The second edition (2004) reaffirmed this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics--expression profiling of genes and proteins--with developmental therapeutics, and the binary state concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. Comprehensive and intellectually stimulating, POMO III not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much neglected gap between information and knowledge, and holds out the hope of new anticancer strategies that will reduce cancer cell proliferation and significantly reduce metastasis.
    Note: Includes bibliographical references and index , Principles of Molecular Oncology; Title Page; Copyright Page; Foreword; Preface; Contents; Contributors; Color Plates; Chapter 1; Chapter 2; Chapter 3; Chapter 4; Chapter 5; Chapter 6; Chapter 7; Chapter 8; Chapter 9; Chapter 10; Chapter 11; Chapter 12; Chapter 13; Chapter 14; Chapter 15; Chapter 16; Chapter 17; Chapter 18; Chapter 19; Chapter 20; Appendix A; Appendix B; Index , Electronic reproduction; Available via World Wide Web
    Additional Edition: 1597454702
    Additional Edition: 9781597454704
    Additional Edition: Print version Principles of Molecular Oncology
    Language: English
    URL: Volltext
    URL: Volltext
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  • 9
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    Online Resource
    Racial differences in a high-risk colorectal cancer referral population: a single-center experience (2011)
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    Details
    UID:
    (DE-101)110953535X
    Format: Online-Ressource , online resource.
    ISSN: 1897-4287 , 1897-4287
    In: volume:9
    In: number:1
    In: day:10
    In: month:3
    In: year:2011
    In: pages:1-2
    In: date:12.2011
    In: Hereditary cancer in clinical practice, Berlin ; Heidelberg : Springer, 2003-, 9, Heft 1 (10.3.2011), 1-2, 12.2011, 1897-4287
    Language: English
    DOI: 10.1186/1897-4287-9-S1-P15
    URN: urn:nbn:de:1111-2016073115015
    URL: https://doi.org/10.1186/1897-4287-9-S1-P15
    URL: https://nbn-resolving.org/urn:nbn:de:1111-2016073115015
    URL: https://d-nb.info/110953535X/34
    URL: http://dx.doi.org/10.1186/1897-4287-9-S1-P15
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  • 10
    Online Resource
    Online Resource
    Principles of Molecular Oncology (2008)
    Totowa, NJ : Humana Press
    Details
    UID:
    (DE-605)HT030660206
    Format: 1 Online-Ressource (XX, 420 p. 85 illus., 21 illus. in color)
    Edition: 3rd ed. 2008
    ISBN: 9781597454704
    Additional Edition: Printed edition 9781603277853
    Additional Edition: Printed edition 9781934115251
    Additional Edition: Printed edition 9781603275057
    Language: English
    DOI: 10.1007/978-1-59745-470-4
    URL: https://doi.org/10.1007/978-1-59745-470-4
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