Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9781402090639
Content:
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Content:
"Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence, cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells, genetics, mechanisms including receptors and signal transduction, mitochondria, proteasome, cytokines, neuro-endocrine-immune networks, inflammation, thymus, clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis, modulation by nutrition, lipids, vaccination and the question ""can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?"""
Note:
Description based upon print version of record
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CONTENTS; Part I. Methods and Models for Studying Immunosenescence; 1. The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies; 2. Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing; 3. Mouse Models and Genetics of Immunosenescence; 4. Insect Models of Immunosenescence; 5. Clonal Culture Models of T-cell Senescence; 6. Mouse Models of Influenza; 7. A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effect of Calorie Restriction
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8. Mathematical Modeling of Immunosenescence: Scenarios, Processes and LimitationsPart II. Cellular Immunosenescene - T Cells; 9. Age, T-cell Homeostasis, and T-cell Diversity in Humans; 10. The Role of T-regulatory Cells in Immune Senescence; 11. Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population; 12. Age-associated T-cell Clonal Expansions (TCE) in vivo-Implications for Pathogen Resistance; 13. T-cell Cycle and Immunosenescence: Role of Aging in the T-cell Proliferative Behaviour and Status Quo Maintenance
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14. Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderly and in the T-cell Clone Longitudinal Model15. Activation-Induced Cell Death of T-cells in Elderly; 16. CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells; 17. Generation and Gene Expression of CD28-CD8 T-cell in Human; 18. Role of Regulatory Subsets During Aging; Cellular Immunosenescence - B Cells; 19. Transcription Factors in Mature B-Cells During Aging; 20. B-Cell Repertoire Changes in Mouse Models of Aging; 21. B-Cells and Antibodies in Old Humans
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Cellular Immunosenescence - Neutrophils22. Neutrophil Granulocyte Functions in the Elderly; 23. Signal Transduction Changes in fMLP, TLRs, TREM-1 and GM-CSF Receptors in PMN with Aging; 24. Synergistic Effects of Ageing and Stress on Neutrophil Function; Cellular Immunosenescence - Antigen Presenting Cells; 25. Role of Dendritic Cells in Aging; 26. Phenotypic and Functional Changes of Circulating Monocytes in Elderly; Cellular Immunosenescence - NK and NKT Cells; 27. NK Cells in Human Ageing; 28. Natural Killer Cells and Human Longevity
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29. The Effects of Age on CD1d-restricted NKT-cells and Their Contribution to Peripheral T-cell ImmunityCellular Immunosenescence - Stem Cells; 30. Lympho-Hematopoietic Stem Cells and Their Aging; 31. Implications of Developmental Switches for Hematopoietic Stem Cell Aging; Cellular Immunosenescence - Genetics; 32. Associations of Cytokine Polymorphisms with Immunosenescence; 33. Cytokine Polymorphisms and Immunosenescence; 34. Role of TLR Polymorphisms in Immunosenescence; Part III. Mechanisms - Receptors and Signal Transduction; 35. Signal Transduction Changes in T-cells with Aging
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36. Molecular Signaling of CD95- and TNFR-Mediated Apoptosis in Naive and Various Memory Subsets of T-Cells
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Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 9781402090622
Language:
English
DOI:
10.1007/978-1-4020-9063-9
URL:
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