In:
Tissue Antigens, Wiley, Vol. 65, No. 2 ( 2005-02), p. 187-191
Abstract:
Abstract: We report here four novel HLA‐B alleles, B*1590, B*1591, B*2726, and B*4705, identified from an East African population during sequence‐based HLA‐B typing. The novel alleles were confirmed by sequencing two separate polymerase chain reaction products, and by molecular cloning and sequencing multiple clones. B*1590 is identical to B*1510 at exon 2 and exon 3, except for a difference (GCCGTC) at codon 158. Sequence differences at codon 152 (GAGGTG) and codon 167 (TGGTCG) differentiate B*1591 from B*1503 at exon 3. B*2726 is identical to B*2708 at exon 2 and exon 3, except for a difference (AAGCAG) at codon 70. B*4705 was identified in three Kenyan women. The allele is identical to B*47010101/02 at exon 2 and exon 3, except for differences at codon 97 (AGGAAT) and codon 99 (TTTTAT). These new alleles have been named by the WHO Nomenclature Committee. Identification of these novel HLA‐B alleles reflects the genetic diversity of this East African population.
Type of Medium:
Online Resource
ISSN:
0001-2815
,
1399-0039
DOI:
10.1111/tan.2005.65.issue-2
DOI:
10.1111/j.1399-0039.2005.00338.x
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
1498140-3
detail.hit.zdb_id:
2844321-4
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