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  • 1
    Online Resource
    Online Resource
    Oncology in the Precision Medicine Era : Value-Based Medicine (2020)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-605)HT020334900
    Format: 1 Online-Ressource (XIII, 351 p. 28 illus., 16 illus. in color)
    Edition: 1st ed. 2020
    ISBN: 9783030314712
    Additional Edition: Printed edition 9783030314705
    Additional Edition: Printed edition 9783030314729
    Additional Edition: Printed edition 9783030314736
    Language: English
    DOI: 10.1007/978-3-030-31471-2
    URL: https://doi.org/10.1007/978-3-030-31471-2
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  • 2
    Online Resource
    Online Resource
    Oncology in the Precision Medicine Era : Value-Based Medicine (2020)
    Cham : Springer International Publishing | Cham : Imprint: Springer
    Details
    UID:
    (DE-627)1686647328
    Format: 1 Online-Ressource(XIII, 351 p. 28 illus., 16 illus. in color.)
    Edition: 1st ed. 2020.
    ISBN: 9783030314712
    Content: Healthcare Perspective -- Lung Cancer -- Esophageal and Gastric Cancer- Sarcomas -- Multiple Myeloma -- Pancreatic Cancer -- Colon Cancer -- Renal Cell Carcinoma -- Prostate Cancer -- Bladder Cancer -- Ovarian Cancer -- Genomic Cancer Risk Assessment -- Triple Negative Breast Cancer -- Melanoma -- Digital Patient Engagement and Social Media -- Hepatocellular Carcinoma -- Head and Neck Cancer -- Primary Central Nervous System Tumors -- Lymphoma.
    Content: This volume comprehensively reviews oncology in the precision medicine era of personalized care, latest developments in the field, and indications and clinical trials for the treatment of cancer with targeted therapies, immunotherapy, and epigenetic modulators. It thoroughly addresses concerns of various types of cancers including cancers of the head and neck, lung, colon, esophagus, bladder, pancreas, and breast; melanoma; multiple myeloma; hepatocellular carcinoma; renal cell carcinoma; and sarcomas. It is organized and written in a format that is easy to follow for both clinicians and non-clinical scientists interested in personalized medicine. Chapters cover the identification of the clinical problem and summary of recent findings, tumor biology and heterogeneity, genomics, examples of simple and complex cases, biological pathways, future clinical trials, and financial considerations. Oncology in the Precision Medicine Era: Value-Based Medicine will serve as a useful resource for medical oncologists and healthcare providers tailoring medicine to the needs of the individual patient, from prevention and diagnosis to treatment and follow up.
    Additional Edition: 9783030314705
    Additional Edition: 9783030314729
    Additional Edition: 9783030314736
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030314705
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030314729
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030314736
    Language: English
    DOI: 10.1007/978-3-030-31471-2
    URL: lizenzpflichtig
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  • 3
    Online Resource
    Online Resource
    Oncology in the Precision Medicine Era : Value-Based Medicine (2020)
    Cham : Springer
    Details
    UID:
    (DE-604)BV046325443
    Format: 1 Online-Ressource (XIII, 351 p. 28 illus., 16 illus. in color)
    ISBN: 9783030314712
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-31470-5
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-31472-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-31473-6
    Language: English
    DOI: 10.1007/978-3-030-31471-2
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 4
    Online Resource
    Online Resource
    Oncology in the Precision Medicine Era : Value-Based Medicine (2019)
    Cham : Springer International Publishing AG
    Details
    UID:
    (DE-627)1751931277
    Format: 1 online resource (352 pages)
    ISBN: 9783030314712
    Content: Intro -- Preface -- Acknowledgments -- Contents -- Contributors -- Chapter 1: Healthcare Perspective -- An Era of Diagnostic and Therapeutic Innovation in Oncology -- Unsustainable Healthcare Expenditures -- The Value Conundrum in Cancer Care -- Creating Transparent, Generalizable Value Models for Oncology -- The Centers for Medicare and Medicaid Services Oncology Care Model (OCM) -- Embracing Necessary Complexity -- The Future of Cancer Care -- References -- Chapter 2: Lung Cancer -- Targeted Therapy in Non-small Cell Lung Cancer -- Epidermal Growth Factor Receptor (EGFR) -- Anaplastic Lymphoma Kinase (ALK) -- ROS Proto-oncogene 1 (ROS1) -- B-Raf Proto-oncogene (BRAF) -- MET Proto-oncogene, Receptor Tyrosine Kinase (MET) -- Ret Proto-oncogene (RET) -- Human Epidermal Growth Factor Receptor 2 (HER2) -- Neurotrophic Tyrosine Kinase (NTRK) -- Immunotherapy in Lung Cancer -- Background -- Biology of Cancer and Immune Therapy -- Immune Checkpoint Inhibitors -- Therapies Targeting CTLA-4 -- PD-1 and PD-L1/PD-L2 Targeted Therapies -- Combination Therapies -- Immunotherapy in Small-Cell Lung Cancer -- Immune-Related Toxicities -- Conclusions -- References -- Chapter 3: Esophageal and Gastric Cancer -- HER2 -- ToGA Trial -- HER2 Testing and Clinical Decision-Making in Gastroesophageal Adenocarcinoma -- GATSBY Trial -- PD-L1 -- Phase I/II Trials -- Phase III Trials -- MSI -- Other Markers -- MET -- EGFR -- Intratumoral Genomic Heterogeneity -- Concluding Remarks -- References -- Chapter 4: Sarcomas -- Targeted Therapies in the Treatment of Advanced STS -- Gastrointestinal Stromal Tumor (GIST) -- Liposarcoma -- Leiomyosarcoma -- Aveolar Soft Part Sarcoma -- Synovial Sarcoma -- Dermatofibrosarcoma Protuberans -- Angiosarcoma -- Role of Immunotherapy in the Treatment of STS -- Summary -- References -- Chapter 5: Multiple Myeloma -- Biology -- Staging.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9783030314705
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030314705
    Language: English
    URL: lizenzpflichtig
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  • 5
    Online Resource
    Online Resource
    Targeted Therapies for Lung Cancer (2019)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-605)HT020115661
    Format: 1 Online-Ressource (IX, 238 p. 19 illus. in color)
    Edition: 1st ed. 2019
    ISBN: 9783030178321
    Series Statement: Current Cancer Research
    Additional Edition: Printed edition 9783030178314
    Additional Edition: Printed edition 9783030178338
    Additional Edition: Printed edition 9783030178345
    Language: English
    DOI: 10.1007/978-3-030-17832-1
    URL: https://doi.org/10.1007/978-3-030-17832-1
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  • 6
    Online Resource
    Online Resource
    Targeted Therapies for Lung Cancer (2019)
    Cham : Springer International Publishing AG
    Details
    UID:
    (DE-627)1751923363
    Format: 1 online resource (244 pages)
    ISBN: 9783030178321
    Series Statement: Current Cancer Research Ser.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9783030178314
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030178314
    Language: English
    URL: lizenzpflichtig
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  • 7
    Online Resource
    Online Resource
    Targeted therapies for lung cancer (2019)
    Cham : Springer
    Details
    UID:
    (DE-627)1668650304
    Format: 1 Online-Ressource (IX, 238 Seiten) , Illustrationen, Diagramme
    ISBN: 9783030178321
    Series Statement: Current cancer research
    Content: 1. EGFR -- 2. ALK -- 3. ROS1 -- 4. B-RAF -- 5. MET -- 6. HER2 -- 7. NTRK -- 8. SCLC -- 9. Complexities of the Lung Tumor Microenvironment -- 10. KRAS -- 11. Targeting Epigenetic Regulators in Cancer to Overcome Targeted Therapy Resistance
    Content: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance
    Additional Edition: 9783030178314
    Additional Edition: Erscheint auch als Druck-Ausgabe 978-3-030-17831-4
    Language: English
    DOI: 10.1007/978-3-030-17832-1
    URL: lizenzpflichtig
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  • 8
    Online Resource
    Online Resource
    Oncology in the Precision Medicine Era : Value-Based Medicine (2020)
    Cham : Springer
    Details
    UID:
    (DE-602)b3kat_BV046325443
    Format: 1 Online-Ressource (XIII, 351 p. 28 illus., 16 illus. in color)
    ISBN: 9783030314712
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-31470-5
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-31472-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-31473-6
    Language: English
    DOI: 10.1007/978-3-030-31471-2
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 9
    Online Resource
    Online Resource
    Targeted Therapies for Lung Cancer (2019)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-604)BV046062598
    Format: 1 Online-Ressource (IX, 238 p. 19 illus. in color)
    Edition: 1st ed. 2019
    ISBN: 9783030178321
    Series Statement: Current Cancer Research
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-17831-4
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-17833-8
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-17834-5
    Language: English
    DOI: 10.1007/978-3-030-17832-1
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 10
    Online Resource
    Online Resource
    Integrating Clinical and Translational Research Networks-Building Team Medicine - Series 2 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    UID:
    (DE-605)HT030381372
    Format: 1 electronic resource (230 pages)
    ISBN: 9783036584737
    Note: English
    Language: English
    URL: DOAB: download the publication
    URL: DOAB: description of the publication
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