In:
eLife, eLife Sciences Publications, Ltd, Vol. 7 ( 2018-09-11)
Abstract:
Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid signaling during neurodevelopment, causing long-lasting deficits. Despite increasing reports of cannabis consumption during pregnancy, the protracted consequences of prenatal cannabinoid exposure (PCE) remain incompletely understood. Here, we report sex-specific differences in behavioral and neuronal deficits in the adult progeny of rat dams exposed to low doses of cannabinoids during gestation. In males, PCE reduced social interaction, ablated endocannabinoid long-term depression (LTD) and heightened excitability of prefrontal cortex pyramidal neurons, while females were spared. Group 1 mGluR and endocannabinoid signaling regulate emotional behavior and synaptic plasticity. Notably, sex-differences following PCE included levels of mGluR1/5 and TRPV1R mRNA. Finally, positive allosteric modulation of mGlu5 and enhancement of anandamide levels restored LTD and social interaction in PCE adult males. Together, these results highlight marked sexual differences in the effects of PCE and introduce strategies for reversing detrimental effects of PCE.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.36234.001
DOI:
10.7554/eLife.36234.002
DOI:
10.7554/eLife.36234.003
DOI:
10.7554/eLife.36234.004
DOI:
10.7554/eLife.36234.005
DOI:
10.7554/eLife.36234.006
DOI:
10.7554/eLife.36234.007
DOI:
10.7554/eLife.36234.008
DOI:
10.7554/eLife.36234.009
DOI:
10.7554/eLife.36234.010
DOI:
10.7554/eLife.36234.011
DOI:
10.7554/eLife.36234.012
DOI:
10.7554/eLife.36234.013
DOI:
10.7554/eLife.36234.014
DOI:
10.7554/eLife.36234.015
DOI:
10.7554/eLife.36234.016
DOI:
10.7554/eLife.36234.017
DOI:
10.7554/eLife.36234.018
DOI:
10.7554/eLife.36234.019
DOI:
10.7554/eLife.36234.020
DOI:
10.7554/eLife.36234.021
DOI:
10.7554/eLife.36234.022
DOI:
10.7554/eLife.36234.024
DOI:
10.7554/eLife.36234.025
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2018
detail.hit.zdb_id:
2687154-3
Bookmarklink