Format:
6
ISSN:
2567-5761
Content:
Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particular, the opposing effects of the protease-activated receptor 1 (PAR-1), dependent on the activating proteases thrombin or activated protein C generated a conundrum researchers only recently have begun to decipher. The net-effect (cellular perturbation vs. cellular protection) depends on co-receptors involved, the concentration of the activating protease, the temporal context of receptor activation, and a dynamic process of receptor rearrangement upon receptor activation. The latter scenario recruits receptors to a cytoprotective signalling pathways. Recent insights into these mechanisms are summarized in this article.
Note:
Gesehen am 30.11.2022
In:
Hämostaseologie, Stuttgart : Thieme, 1981, 31(2011), 03, Seite 179-184, 2567-5761
In:
volume:31
In:
year:2011
In:
number:03
In:
pages:179-184
In:
extent:6
Additional Edition:
Erscheint auch als Druck-Ausgabe Shahzad Hussain, Khurrum, 1981 - The evolving plasticity of coagulation protease-dependent cytoprotective signalling 2011
Language:
English
URL:
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