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  • 1
    UID:
    (DE-101)1047449307
    Format: III, 99 S. , graph. Darst. , 21 cm
    Edition: 1. Aufl.
    ISBN: 9783942789165
    Series Statement: E.ON Energy Research Center 17 : PGS, power generation and storage systems
    Note: Zugl.: Aachen, Techn. Hochsch., Diss., 2013
    Language: English
    Keywords: Hochschulschrift
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  • 2
    Book
    Book
    München : Herbert Utz Verlag
    UID:
    (DE-603)36609260X
    Format: xiv, 194 Seiten , Illustrationen , 21 cm, 291 g
    ISBN: 9783831645206 , 3831645205
    Series Statement: Forschungsberichte / IWB Band 305
    Note: Dissertation Technische Universität München 2015
    Language: German
    Subjects: Economics
    RVK:
    Keywords: Hochschulschrift
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  • 3
    UID:
    (DE-627)858859238
    Format: 1 Online-Ressource
    Content: This thesis contains two main parts: (1) Developing a new screening strategy and identifying candidates for anticancer drugs with DNA replication-initiation proteins as the targets; (2) Identifying and characterizing Rrp12p as a novel DNA replication-initiation protein. In the first part, eukaryotic DNA replication is tightly controlled by DNA replication-initiation proteins and cell cycle check points to ensure that the genome is exactly copied once per cell cycle. Different from normal cells, most of cancer cells are deficient in the check point systems and have over-expression of DNA replication-initiation proteins. Therefore DNA replication-initiation proteins are excellent targets for cancer therapy. Inhibiting the replication-initiation proteins such as MCM (Minichromosome Maintenance) proteins effectively damages DNA replication of cancer cells and induces cancer cell apoptosis, leaving normal cell mostly unharmed. To develop novel anticancer drugs that inhibit DNA replication, a preliminary screen platform was set up to test chemicals from a traditional Chinese medicine library (TCM). A fraction (numbered 303) of a tropical plant was identified from the screening platform. It specifically disrupts the interaction of MCM proteins in the yeast two-hybrid system, and induces cancer cells to undergo apoptosis in human cancer cell lines. In anticancer mechanism studies, fraction 303 inhibits DNA replication of cancer cells as determined by the BrdU assay, and affects the localizations of MCM-GFP proteins in cancer cells. Chromatin binding assays indicate that fraction 303 affects binding abilities of MCM proteins on chromatin. FACS results of block-and-release experiments show that fraction 303 arrests the cancer cells in G1 phase, and leads them to pro-apoptotic status. From these data, the anticancer mechanism of fraction 303 is that it disrupts the interaction of MCM protein and inhibits the formation of pre-replication complex (pre-RC) on chromatin. Consequently, incomplete DNA replication induces cancer cell apoptosis. Therefore, fraction 303 is a promising anticancer drug candidate. In the second part, Rrp12p as a novel DNA replication-initiation protein was identified and characterized. In Saccharomyces cerevisiae, initiation of DNA replication (IDR) requires replication-initiation proteins and the replicator elements. Identification and characterization of DNA replication-initiation proteins have advanced our understanding of eukaryotic DNA replication. A novel IDR gene, RRP12 (Ribosomal RNA Processing protein 12) was identified by screening a collection of td (temperature-sensitive degron) mutants by using the colony size assay. FACS analysis in block-and-release experiments indicates that Rrp12p is required for the initiation of DNA replication, but not for replication elongation or mitosis. Reciprocal co-immunoprecipitation experiments show that Rrp12p interacts with Mcm2p. Moreover, overexpression of RRP12 suppresses the temperature sensitive lethal phenotype of mcm3-1 mutant. These data suggest that Rrp12p is an essential DNA replication-initiation protein and plays roles in the assembly of pre-RC complex.
    Note: Dissertation 2008
    Language: English
    Keywords: Hochschulschrift
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  • 4
    UID:
    (DE-627)1185141340
    Format: 78 Bl. , Ill., graph. Darst.
    Note: Dresden, Techn. Univ., Diss., 2004
    Language: English
    Subjects: Biology
    RVK:
    RVK:
    Keywords: Drosophila ; Morphogenese ; Signaltransduktion ; Decapentaplegic ; Hochschulschrift
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  • 5
    UID:
    (DE-627)1757787798
    Note: Beitrag nicht enthalten
    In: Harmony between man & nature ; Vol. 8, Piscataway, NJ : IEEE Operations Center, 2005, 2005, n/a
    In: year:2005
    Language: English
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  • 6
    UID:
    (DE-602)b3kat_BV024999837
    Format: 183 S.
    Edition: 1. Aufl.
    ISBN: 7805674167
    Language: English
    Subjects: Comparative Studies. Non-European Languages/Literatures
    RVK:
    Keywords: Fiktionale Darstellung
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  • 7
    Online Resource
    Online Resource
    Oxford : Chandos
    UID:
    (DE-604)BV042300328
    Format: 1 Online-Ressource (xiv, 164 pages)
    ISBN: 9781780632278 , 1780632274 , 1306379490 , 9781306379496 , 9781843341802 , 1843341808
    Series Statement: Chandos Asian studies series
    Note: Includes bibliographical references (pages 147-157) and index , The scale, nature and causes of labour disputes in China are identified and discussed in this comprehensive review as well as how they can be managed. The labour disputes resolution mechanisms discussed in this book include, trade union, collective labour contract, tripartite coordination and labour court. This book presents an updated literature review and reports the findings of two empirical projects on this subject. The effectiveness of these mechanisms and the appropriate resolution model for the future are both discussed. Systematic and critical review of the up-to-date literature on labour disputes and their managementEmpirical findings on labour disputes and the institutional channels available to workers for resolving themAssessment of the effectiveness of the existing mechanisms for dealing with labour disputes
    Language: English
    Keywords: China ; Arbeitsbeziehungen ; China ; Arbeitskampf
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  • 8
    Online Resource
    Online Resource
    Oxford : Chandos
    UID:
    (DE-605)HT018383425
    Format: XIV, 164 S. , graph. Darst
    Edition: Online-Ausg 2014
    ISBN: 9781780632278
    Additional Edition: Erscheint auch als Druck-Ausgabe 1843341808
    Additional Edition: Erscheint auch als Druck-Ausgabe 9781843341802
    Language: English
    Keywords: China ; Arbeitsbeziehungen ; China ; Arbeitskampf
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  • 9
    UID:
    (DE-627)516293125
    Format: Online-Ressource
    Note: Freiburg (Breisgau), Univ., Diss, 2006
    Language: German
    Keywords: Hochschulschrift
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  • 10
    Book
    Book
    Oxford : Chandos Publ.
    UID:
    (DE-627)516309102
    Format: XIV, 164 S. , graph. Darst. , 24cm
    ISBN: 1843341808 , 9781843341802
    Series Statement: Chandos Asian studies series
    Language: English
    Subjects: Economics
    RVK:
    Keywords: China ; Arbeitsbeziehungen ; Gewerkschaft ; Arbeitskonflikt ; China ; Arbeitskonflikt ; Arbeitsbeziehungen ; Schlichtung ; Gewerkschaft
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